Hyman BT - Search Results

1

Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau.

Mate de Gerando A, Welikovitch LA, Khasnavis A, Commins C, Glynn C, Chun JE, Perbet R, Hyman BT. Mate de Gerando A, et al. Among authors: hyman bt. bioRxiv [Preprint]. 2023 May 26:2023.03.28.534418. doi: 10.1101/2023.03.28.534418. bioRxiv. 2023. Update in: Acta Neuropathol. 2023 Aug;146(2):191-210. doi: 10.1007/s00401-023-02600-1. PMID: 37034629 Free PMC article. Updated. Preprint.

2

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.

Takeda S, Wegmann S, Cho H, DeVos SL, Commins C, Roe AD, Nicholls SB, Carlson GA, Pitstick R, Nobuhara CK, Costantino I, Frosch MP, Müller DJ, Irimia D, Hyman BT. Takeda S, et al. Among authors: hyman bt. Nat Commun. 2015 Oct 13;6:8490. doi: 10.1038/ncomms9490. Nat Commun. 2015. PMID: 26458742 Free PMC article.

3

Characterization of TauC3 antibody and demonstration of its potential to block tau propagation.

Nicholls SB, DeVos SL, Commins C, Nobuhara C, Bennett RE, Corjuc DL, Maury E, Eftekharzadeh B, Akingbade O, Fan Z, Roe AD, Takeda S, Wegmann S, Hyman BT. Nicholls SB, et al. Among authors: hyman bt. PLoS One. 2017 May 22;12(5):e0177914. doi: 10.1371/journal.pone.0177914. eCollection 2017. PLoS One. 2017. PMID: 28531180 Free PMC article.

4

Tau protein liquid-liquid phase separation can initiate tau aggregation.

Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska KM, Bennett RE, Dujardin S, Laskowski PR, MacKenzie D, Kamath T, Commins C, Vanderburg C, Roe AD, Fan Z, Molliex AM, Hernandez-Vega A, Muller D, Hyman AA, Mandelkow E, Taylor JP, Hyman BT. Wegmann S, et al. Among authors: hyman aa, hyman bt. EMBO J. 2018 Apr 3;37(7):e98049. doi: 10.15252/embj.201798049. Epub 2018 Feb 22. EMBO J. 2018. PMID: 29472250 Free PMC article.

5

Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo.

DeVos SL, Corjuc BT, Commins C, Dujardin S, Bannon RN, Corjuc D, Moore BD, Bennett RE, Jorfi M, Gonzales JA, Dooley PM, Roe AD, Pitstick R, Irimia D, Frosch MP, Carlson GA, Hyman BT. DeVos SL, et al. Among authors: hyman bt. Brain. 2018 Jul 1;141(7):2194-2212. doi: 10.1093/brain/awy117. Brain. 2018. PMID: 29733334 Free PMC article.

6

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain.

DeVos SL, Corjuc BT, Oakley DH, Nobuhara CK, Bannon RN, Chase A, Commins C, Gonzalez JA, Dooley PM, Frosch MP, Hyman BT. DeVos SL, et al. Among authors: hyman bt. Front Neurosci. 2018 Apr 24;12:267. doi: 10.3389/fnins.2018.00267. eCollection 2018. Front Neurosci. 2018. PMID: 29740275 Free PMC article.

7

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo.

Busche MA, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, Kamath TV, Carlson GA, Nelken I, Hyman BT. Busche MA, et al. Among authors: hyman bt. Nat Neurosci. 2019 Jan;22(1):57-64. doi: 10.1038/s41593-018-0289-8. Epub 2018 Dec 17. Nat Neurosci. 2019. PMID: 30559471 Free PMC article.

8

The Alzheimer Disease-Causing Presenilin-1 L435F Mutation Causes Increased Production of Soluble Aβ43 Species in Patient-Derived iPSC-Neurons, Closely Mimicking Matched Patient Brain Tissue.

Oakley DH, Chung M, Klickstein N, Commins C, Hyman BT, Frosch MP. Oakley DH, et al. Among authors: hyman bt. J Neuropathol Exp Neurol. 2020 Jun 1;79(6):592-604. doi: 10.1093/jnen/nlaa025. J Neuropathol Exp Neurol. 2020. PMID: 32388561 Free PMC article.

9

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.

Dujardin S, Commins C, Lathuiliere A, Beerepoot P, Fernandes AR, Kamath TV, De Los Santos MB, Klickstein N, Corjuc DL, Corjuc BT, Dooley PM, Viode A, Oakley DH, Moore BD, Mullin K, Jean-Gilles D, Clark R, Atchison K, Moore R, Chibnik LB, Tanzi RE, Frosch MP, Serrano-Pozo A, Elwood F, Steen JA, Kennedy ME, Hyman BT. Dujardin S, et al. Among authors: hyman bt. Nat Med. 2020 Aug;26(8):1256-1263. doi: 10.1038/s41591-020-0938-9. Epub 2020 Jun 22. Nat Med. 2020. PMID: 32572268 Free PMC article.

10

Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds.

Perez-Rando M, Dujardin S, Bennett RE, Commins C, Nibhanupudy T, Hyman BT. Perez-Rando M, et al. Among authors: hyman bt. Acta Neuropathol Commun. 2020 Oct 19;8(1):168. doi: 10.1186/s40478-020-01049-7. Acta Neuropathol Commun. 2020. PMID: 33076986 Free PMC article.

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