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Structural design, synthesis, and anti-Trypanosomatidae profile of new Pyridyl-thiazolidinones.
Conceição JMD, Santos ACDS, Brayner FA, Alves LC, Pinto AF, Brondani GL, Oliveira Filho GB, Bedor DCG, Silva JWVD, Sales Junior PA, Cavalcante MKA, Silva EDD, Pereira VRA, Leite ACL. Conceição JMD, et al. Among authors: pereira vra. Eur J Med Chem. 2023 Jun 5;254:115310. doi: 10.1016/j.ejmech.2023.115310. Epub 2023 Apr 6. Eur J Med Chem. 2023. PMID: 37062170
Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice.
Moreira DR, Costa SP, Hernandes MZ, Rabello MM, de Oliveira Filho GB, de Melo CM, da Rocha LF, de Simone CA, Ferreira RS, Fradico JR, Meira CS, Guimarães ET, Srivastava RM, Pereira VR, Soares MB, Leite AC. Moreira DR, et al. J Med Chem. 2012 Dec 27;55(24):10918-36. doi: 10.1021/jm301518v. Epub 2012 Dec 7. J Med Chem. 2012. PMID: 23167554
Evaluation of the anti-Schistosoma mansoni activity of thiosemicarbazones and thiazoles.
Santiago Ede F, de Oliveira SA, de Oliveira Filho GB, Moreira DR, Gomes PA, da Silva AL, de Barros AF, da Silva AC, Dos Santos TA, Pereira VR, Gonçalves GG, Brayner FA, Alves LC, Wanderley AG, Leite AC. Santiago Ede F, et al. Antimicrob Agents Chemother. 2014;58(1):352-63. doi: 10.1128/AAC.01900-13. Epub 2013 Oct 28. Antimicrob Agents Chemother. 2014. PMID: 24165185 Free PMC article.
Conformational restriction of aryl thiosemicarbazones produces potent and selective anti-Trypanosoma cruzi compounds which induce apoptotic parasite death.
Magalhaes Moreira DR, de Oliveira AD, Teixeira de Moraes Gomes PA, de Simone CA, Villela FS, Ferreira RS, da Silva AC, dos Santos TA, Brelaz de Castro MC, Pereira VR, Leite AC. Magalhaes Moreira DR, et al. Eur J Med Chem. 2014 Mar 21;75:467-78. doi: 10.1016/j.ejmech.2014.02.001. Epub 2014 Feb 3. Eur J Med Chem. 2014. PMID: 24561675
Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain.
Espíndola JW, Cardoso MV, Filho GB, Oliveira E Silva DA, Moreira DR, Bastos TM, Simone CA, Soares MB, Villela FS, Ferreira RS, Castro MC, Pereira VR, Murta SM, Sales Junior PA, Romanha AJ, Leite AC. Espíndola JW, et al. Eur J Med Chem. 2015 Aug 28;101:818-35. doi: 10.1016/j.ejmech.2015.06.048. Epub 2015 Jul 3. Eur J Med Chem. 2015. PMID: 26231082
107 results