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In Vivo Antileishmanial Effect of 3,5-Diaryl-isoxazole Analogues Based on Veraguensin, Grandisin, and Machilin G: A Glance at a Preclinical Study.
das Neves AR, Carvalho DB, Silva F, Rosalem RF, Pelizaro BI, Castilho PF, Oliveira KMP, Cassemiro NS, Pessatto LR, Paredes-Gamero EJ, Piranda EM, Silva DB, Arruda CCP, Baroni ACM. das Neves AR, et al. ACS Infect Dis. 2023 May 12;9(5):1150-1159. doi: 10.1021/acsinfecdis.3c00090. Epub 2023 Apr 27. ACS Infect Dis. 2023. PMID: 37103973
Design, synthesis and antitrypanosomatid activities of 3,5-diaryl-isoxazole analogues based on neolignans veraguensin, grandisin and machilin G.
Trefzger OS, das Neves AR, Barbosa NV, Carvalho DB, Pereira IC, Perdomo RT, Matos MFC, Yoshida NC, Kato MJ, de Albuquerque S, Arruda CCP, Baroni ACM. Trefzger OS, et al. Among authors: das neves ar. Chem Biol Drug Des. 2019 Mar;93(3):313-324. doi: 10.1111/cbdd.13417. Epub 2018 Nov 25. Chem Biol Drug Des. 2019. PMID: 30354012
Effect of isoxazole derivatives of tetrahydrofuran neolignans on intracellular amastigotes of Leishmania (Leishmania) amazonensis: A structure-activity relationship comparative study with triazole-neolignan-based compounds.
das Neves AR, Trefzger OS, Barbosa NV, Honorato AM, Carvalho DB, Moslaves IS, Kadri MCT, Yoshida NC, Kato MJ, Arruda CCP, Baroni ACM. das Neves AR, et al. Chem Biol Drug Des. 2019 Dec;94(6):2004-2012. doi: 10.1111/cbdd.13609. Epub 2019 Sep 12. Chem Biol Drug Des. 2019. PMID: 31444858
Design, synthesis, antileishmanial, and antifungal biological evaluation of novel 3,5-disubstituted isoxazole compounds based on 5-nitrofuran scaffolds.
Trefzger OS, Barbosa NV, Scapolatempo RL, das Neves AR, Ortale MLFS, Carvalho DB, Honorato AM, Fragoso MR, Shuiguemoto CYK, Perdomo RT, Matos MFC, Chang MR, Arruda CCP, Baroni ACM. Trefzger OS, et al. Among authors: das neves ar. Arch Pharm (Weinheim). 2020 Feb;353(2):e1900241. doi: 10.1002/ardp.201900241. Epub 2019 Dec 16. Arch Pharm (Weinheim). 2020. PMID: 31840866
Repurposing of 5-nitrofuran-3,5-disubstituted isoxazoles: A thriving scaffold to antitrypanosomal agents.
Carvalho DB, das Neves AR, Portapilla GB, Soares O, Santos LBB, Oliveira JRS, Vianna LS, Judice WAS, Cardoso IA, Luccas PH, Nonato MC, Lopes NP, de Albuquerque S, Baroni ACM. Carvalho DB, et al. Among authors: das neves ar. Arch Pharm (Weinheim). 2023 Apr;356(4):e2200472. doi: 10.1002/ardp.202200472. Epub 2022 Dec 19. Arch Pharm (Weinheim). 2023. PMID: 36534890
Design, synthesis and antitrypanosomatid activity of 2-nitroimidazole-3,5-disubstituted isoxazole compounds based on benznidazole.
Carvalho DB, Costa PAN, Portapilla GB, das Neves AR, Shiguemoto CYK, Pelizaro BI, Silva F, Piranda EM, Arruda CCP, Gaspari PDM, Cardoso IA, Luccas PH, Nonato MC, Lopes NP, de Albuquerque S, Baroni ACM. Carvalho DB, et al. Among authors: das neves ar. Eur J Med Chem. 2023 Nov 15;260:115451. doi: 10.1016/j.ejmech.2023.115451. Epub 2023 May 5. Eur J Med Chem. 2023. PMID: 37573209
Investigation of the Potential Targets behind the Promising and Highly Selective Antileishmanial Action of Synthetic Flavonoid Derivatives.
Lourenço EMG, da Silva F, das Neves AR, Bonfá IS, Ferreira AMT, Menezes ACG, da Silva MEC, Dos Santos JT, Martines MAU, Perdomo RT, Toffoli-Kadri MC, G Barbosa E, Saba S, Beatriz A, Rafique J, de Arruda CCP, de Lima DP. Lourenço EMG, et al. Among authors: das neves ar. ACS Infect Dis. 2023 Oct 13;9(10):2048-2061. doi: 10.1021/acsinfecdis.3c00336. Epub 2023 Sep 29. ACS Infect Dis. 2023. PMID: 37772925
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