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USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities.
Perurena N, Lock R, Davis RA, Raghavan S, Pilla NF, Ng R, Loi P, Guild CJ, Miller AL, Sicinska E, Cleary JM, Rubinson DA, Wolpin BM, Gray NS, Santagata S, Hahn WC, Morton JP, Sansom OJ, Aguirre AJ, Cichowski K. Perurena N, et al. Among authors: cichowski k. Cell Rep Med. 2023 Apr 18;4(4):101007. doi: 10.1016/j.xcrm.2023.101007. Epub 2023 Apr 7. Cell Rep Med. 2023. PMID: 37030295 Free PMC article.
Combinatorial strategies to target RAS-driven cancers.
Perurena N, Situ L, Cichowski K. Perurena N, et al. Among authors: cichowski k. Nat Rev Cancer. 2024 May;24(5):316-337. doi: 10.1038/s41568-024-00679-6. Epub 2024 Apr 16. Nat Rev Cancer. 2024. PMID: 38627557 Review.
Author Correction: An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB.
Min J, Zaslavsky A, Fedele G, McLaughlin SK, Reczek EE, De Raedt T, Guney I, Strochlic DE, MacConaill LE, Beroukhim R, Bronson RT, Ryeom S, Hahn WC, Loda M, Cichowski K. Min J, et al. Among authors: cichowski k. Nat Med. 2024 Feb 21. doi: 10.1038/s41591-024-02866-2. Online ahead of print. Nat Med. 2024. PMID: 38383797 No abstract available.
Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity.
Zhang Y, Guillermier C, De Raedt T, Cox AG, Maertens O, Yimlamai D, Lun M, Whitney A, Maas RL, Goessling W, Cichowski K, Steinhauser ML. Zhang Y, et al. Among authors: cichowski k. iScience. 2020 Aug 21;23(8):101355. doi: 10.1016/j.isci.2020.101355. Epub 2020 Jul 10. iScience. 2020. PMID: 32712466 Free PMC article.
A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers.
Guerra SL, Maertens O, Kuzmickas R, De Raedt T, Adeyemi RO, Guild CJ, Guillemette S, Redig AJ, Chambers ES, Xu M, Tiv H, Santagata S, Jänne PA, Elledge SJ, Cichowski K. Guerra SL, et al. Among authors: cichowski k. Cancer Cell. 2020 May 11;37(5):705-719.e6. doi: 10.1016/j.ccell.2020.03.004. Epub 2020 Apr 2. Cancer Cell. 2020. PMID: 32243838 Free PMC article.
IL1α Antagonizes IL1β and Promotes Adaptive Immune Rejection of Malignant Tumors.
Tian T, Lofftus S, Pan Y, Stingley CA, King SL, Zhao J, Pan TY, Lock R, Marglous JW, Liu K, Widlund HR, Fuhlbrigge RC, Cichowski K, Kupper TS. Tian T, et al. Among authors: cichowski k. Cancer Immunol Res. 2020 May;8(5):660-671. doi: 10.1158/2326-6066.CIR-19-0552. Epub 2020 Mar 11. Cancer Immunol Res. 2020. PMID: 32161110 Free PMC article.
Targeting Refractory Sarcomas and Malignant Peripheral Nerve Sheath Tumors in a Phase I/II Study of Sirolimus in Combination with Ganetespib (SARC023).
Kim A, Lu Y, Okuno SH, Reinke D, Maertens O, Perentesis J, Basu M, Wolters PL, De Raedt T, Chawla S, Chugh R, Van Tine BA, O'Sullivan G, Chen A, Cichowski K, Widemann BC. Kim A, et al. Among authors: cichowski k. Sarcoma. 2020 Jan 30;2020:5784876. doi: 10.1155/2020/5784876. eCollection 2020. Sarcoma. 2020. PMID: 32089640 Free PMC article.
64 results