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Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection.
Vu MN, Alvarado RE, Morris DR, Lokugamage KG, Zhou Y, Morgan AL, Estes LK, McLeland AM, Schindewolf C, Plante JA, Ahearn YP, Meyers WM, Murray JT, Crocquet-Valdes PA, Weaver SC, Walker DH, Russell WK, Routh AL, Plante KS, Menachery V. Vu MN, et al. bioRxiv [Preprint]. 2023 Jul 10:2023.04.17.536926. doi: 10.1101/2023.04.17.536926. bioRxiv. 2023. PMID: 37131784 Free PMC article. Preprint.
Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis.
Johnson BA, Xie X, Kalveram B, Lokugamage KG, Muruato A, Zou J, Zhang X, Juelich T, Smith JK, Zhang L, Bopp N, Schindewolf C, Vu M, Vanderheiden A, Swetnam D, Plante JA, Aguilar P, Plante KS, Lee B, Weaver SC, Suthar MS, Routh AL, Ren P, Ku Z, An Z, Debbink K, Shi PY, Freiberg AN, Menachery VD. Johnson BA, et al. bioRxiv [Preprint]. 2020 Aug 26:2020.08.26.268854. doi: 10.1101/2020.08.26.268854. bioRxiv. 2020. Update in: Nature. 2021 Mar;591(7849):293-299. doi: 10.1038/s41586-021-03237-4. PMID: 32869021 Free PMC article. Updated. Preprint.
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.
Johnson BA, Xie X, Bailey AL, Kalveram B, Lokugamage KG, Muruato A, Zou J, Zhang X, Juelich T, Smith JK, Zhang L, Bopp N, Schindewolf C, Vu M, Vanderheiden A, Winkler ES, Swetnam D, Plante JA, Aguilar P, Plante KS, Popov V, Lee B, Weaver SC, Suthar MS, Routh AL, Ren P, Ku Z, An Z, Debbink K, Diamond MS, Shi PY, Freiberg AN, Menachery VD. Johnson BA, et al. Nature. 2021 Mar;591(7849):293-299. doi: 10.1038/s41586-021-03237-4. Epub 2021 Jan 25. Nature. 2021. PMID: 33494095 Free PMC article.
Engineering SARS-CoV-2 using a reverse genetic system.
Xie X, Lokugamage KG, Zhang X, Vu MN, Muruato AE, Menachery VD, Shi PY. Xie X, et al. Among authors: vu mn. Nat Protoc. 2021 Mar;16(3):1761-1784. doi: 10.1038/s41596-021-00491-8. Epub 2021 Jan 29. Nat Protoc. 2021. PMID: 33514944 Free PMC article. Review.
Nucleocapsid vaccine elicits spike-independent SARS-CoV-2 protective immunity.
Matchett WE, Joag V, Stolley JM, Shepherd FK, Quarnstrom CF, Mickelson CK, Wijeyesinghe S, Soerens AG, Becker S, Thiede JM, Weyu E, O'Flanagan S, Walter JA, Vu MN, Menachery VD, Bold TD, Vezys V, Jenkins MK, Langlois RA, Masopust D. Matchett WE, et al. Among authors: vu mn. bioRxiv [Preprint]. 2021 Apr 27:2021.04.26.441518. doi: 10.1101/2021.04.26.441518. bioRxiv. 2021. Update in: J Immunol. 2021 Jul 15;207(2):376-379. doi: 10.4049/jimmunol.2100421. PMID: 33948591 Free PMC article. Updated. Preprint.
Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge.
Muruato A, Vu MN, Johnson BA, Davis-Gardner ME, Vanderheiden A, Lokugmage K, Schindewolf C, Crocquet-Valdes PA, Langsjoen RM, Plante JA, Plante KS, Weaver SC, Debbink K, Routh AL, Walker D, Suthar MS, Xie X, Shi PY, Xie X, Menachery VD. Muruato A, et al. Among authors: vu mn. bioRxiv [Preprint]. 2021 May 4:2021.05.03.442357. doi: 10.1101/2021.05.03.442357. bioRxiv. 2021. Update in: PLoS Biol. 2021 Nov 4;19(11):e3001284. doi: 10.1371/journal.pbio.3001284. PMID: 33972939 Free PMC article. Updated. Preprint.
Cutting Edge: Nucleocapsid Vaccine Elicits Spike-Independent SARS-CoV-2 Protective Immunity.
Matchett WE, Joag V, Stolley JM, Shepherd FK, Quarnstrom CF, Mickelson CK, Wijeyesinghe S, Soerens AG, Becker S, Thiede JM, Weyu E, O'Flanagan SD, Walter JA, Vu MN, Menachery VD, Bold TD, Vezys V, Jenkins MK, Langlois RA, Masopust D. Matchett WE, et al. Among authors: vu mn. J Immunol. 2021 Jul 15;207(2):376-379. doi: 10.4049/jimmunol.2100421. Epub 2021 Jun 30. J Immunol. 2021. PMID: 34193597 Free PMC article.
Binding and entering: COVID finds a new home.
Vu MN, Menachery VD. Vu MN, et al. PLoS Pathog. 2021 Aug 30;17(8):e1009857. doi: 10.1371/journal.ppat.1009857. eCollection 2021 Aug. PLoS Pathog. 2021. PMID: 34460863 Free PMC article. Review.
Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis.
Johnson BA, Zhou Y, Lokugamage KG, Vu MN, Bopp N, Crocquet-Valdes PA, Kalveram B, Schindewolf C, Liu Y, Scharton D, Plante JA, Xie X, Aguilar P, Weaver SC, Shi PY, Walker DH, Routh AL, Plante KS, Menachery VD. Johnson BA, et al. Among authors: vu mn. bioRxiv [Preprint]. 2022 Mar 28:2021.10.14.464390. doi: 10.1101/2021.10.14.464390. bioRxiv. 2022. Update in: PLoS Pathog. 2022 Jun 21;18(6):e1010627. doi: 10.1371/journal.ppat.1010627. PMID: 34671771 Free PMC article. Updated. Preprint.
47 results