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The highly selective and oral phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib induces apoptosis in mesothelioma cells and increases immune effector cell composition.
Kalla C, Ott G, Finotello F, Niewola-Staszkowska K, Conza GD, Lahn M, van der Veen L, Schüler J, Falkenstern-Ge R, Kopecka J, Riganti C. Kalla C, et al. Among authors: ott g. Transl Oncol. 2024 May;43:101857. doi: 10.1016/j.tranon.2023.101857. Epub 2024 Feb 27. Transl Oncol. 2024. PMID: 38412661 Free PMC article.
Pulmonary cancers across different histotypes share hybrid tuft cell/ionocyte-like molecular features and potentially druggable vulnerabilities.
Yamada Y, Belharazem-Vitacolonnna D, Bohnenberger H, Weiß C, Matsui N, Kriegsmann M, Kriegsmann K, Sinn P, Simon-Keller K, Hamilton G, Graeter T, Preissler G, Ott G, Schölch S, Nakajima N, Yoshizawa A, Haga H, Date H, Thomas RK, Petrini I, Giaccone G, Ströbel P, Marx A. Yamada Y, et al. Among authors: ott g. Cell Death Dis. 2022 Nov 19;13(11):979. doi: 10.1038/s41419-022-05428-x. Cell Death Dis. 2022. PMID: 36402755 Free PMC article.
783 results