Pospiech H - Search Results

1

ABRAXAS1 orchestrates BRCA1 activities to counter genome destabilizing repair pathways-lessons from breast cancer patients.

Sachsenweger J, Jansche R, Merk T, Heitmeir B, Deniz M, Faust U, Roggia C, Tzschach A, Schroeder C, Riess A, Pospiech H, Peltoketo H, Pylkäs K, Winqvist R, Wiesmüller L. Sachsenweger J, et al. Among authors: pospiech h. Cell Death Dis. 2023 May 17;14(5):328. doi: 10.1038/s41419-023-05845-6. Cell Death Dis. 2023. PMID: 37198153 Free PMC article.

2

Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients.

Obermeier K, Sachsenweger J, Friedl TW, Pospiech H, Winqvist R, Wiesmüller L. Obermeier K, et al. Among authors: pospiech h. Oncogene. 2016 Jul 21;35(29):3796-806. doi: 10.1038/onc.2015.448. Epub 2015 Dec 7. Oncogene. 2016. PMID: 26640152 Free PMC article.

3

BRCA1 mislocalization leads to aberrant DNA damage response in heterozygous ABRAXAS1 mutation carrier cells.

Bose M, Sachsenweger J, Laurila N, Parplys AC, Willmann J, Jungwirth J, Groth M, Rapakko K, Nieminen P, Friedl TWP, Heiserich L, Meyer F, Tuppurainen H, Peltoketo H, Nevanlinna H, Pylkäs K, Borgmann K, Wiesmüller L, Winqvist R, Pospiech H. Bose M, et al. Among authors: pospiech h. Hum Mol Genet. 2019 Dec 15;28(24):4148-4160. doi: 10.1093/hmg/ddz252. Hum Mol Genet. 2019. PMID: 31630195

4

Heterozygous mutations in PALB2 cause DNA replication and damage response defects.

Nikkilä J, Parplys AC, Pylkäs K, Bose M, Huo Y, Borgmann K, Rapakko K, Nieminen P, Xia B, Pospiech H, Winqvist R. Nikkilä J, et al. Among authors: pospiech h. Nat Commun. 2013;4:2578. doi: 10.1038/ncomms3578. Nat Commun. 2013. PMID: 24153426 Free PMC article.

5

Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance.

Biber S, Pospiech H, Gottifredi V, Wiesmüller L. Biber S, et al. Among authors: pospiech h. Nucleic Acids Res. 2020 Dec 2;48(21):12188-12203. doi: 10.1093/nar/gkaa974. Nucleic Acids Res. 2020. PMID: 33166398 Free PMC article.

6

Identification of a common polymorphism in the TopBP1 gene associated with hereditary susceptibility to breast and ovarian cancer.

Karppinen SM, Erkko H, Reini K, Pospiech H, Heikkinen K, Rapakko K, Syväoja JE, Winqvist R. Karppinen SM, et al. Among authors: pospiech h. Eur J Cancer. 2006 Oct;42(15):2647-52. doi: 10.1016/j.ejca.2006.05.030. Epub 2006 Aug 23. Eur J Cancer. 2006. PMID: 16930991

7

The intrinsically disordered amino-terminal region of human RecQL4: multiple DNA-binding domains confer annealing, strand exchange and G4 DNA binding.

Keller H, Kiosze K, Sachsenweger J, Haumann S, Ohlenschläger O, Nuutinen T, Syväoja JE, Görlach M, Grosse F, Pospiech H. Keller H, et al. Among authors: pospiech h. Nucleic Acids Res. 2014 Nov 10;42(20):12614-27. doi: 10.1093/nar/gku993. Epub 2014 Oct 21. Nucleic Acids Res. 2014. PMID: 25336622 Free PMC article.

8

DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression.

Hampp S, Kiessling T, Buechle K, Mansilla SF, Thomale J, Rall M, Ahn J, Pospiech H, Gottifredi V, Wiesmüller L. Hampp S, et al. Among authors: pospiech h. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4311-9. doi: 10.1073/pnas.1605828113. Epub 2016 Jul 12. Proc Natl Acad Sci U S A. 2016. PMID: 27407148 Free PMC article.

9

S100A11 plays a role in homologous recombination and genome maintenance by influencing the persistence of RAD51 in DNA repair foci.

Foertsch F, Szambowska A, Weise A, Zielinski A, Schlott B, Kraft F, Mrasek K, Borgmann K, Pospiech H, Grosse F, Melle C. Foertsch F, et al. Among authors: pospiech h. Cell Cycle. 2016 Oct 17;15(20):2766-79. doi: 10.1080/15384101.2016.1220457. Epub 2016 Aug 11. Cell Cycle. 2016. PMID: 27590262 Free PMC article.

10

Partial Reduction in BRCA1 Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance.

Classen S, Rahlf E, Jungwirth J, Albers N, Hebestreit LP, Zielinski A, Poole L, Groth M, Koch P, Liehr T, Kankel S, Cordes N, Petersen C, Rothkamm K, Pospiech H, Borgmann K. Classen S, et al. Among authors: pospiech h. Int J Mol Sci. 2022 Nov 1;23(21):13363. doi: 10.3390/ijms232113363. Int J Mol Sci. 2022. PMID: 36362151 Free PMC article.

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