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Di-fluoro azepane HBV capsid assembly modulators.
DeRatt LG, Stoops B, Shaffer P, Lam AM, Espiritu C, Vogel R, Lau V, Flores OA, Kuduk SD. DeRatt LG, et al. Among authors: kuduk sd. Bioorg Med Chem Lett. 2023 Aug 15;92:129350. doi: 10.1016/j.bmcl.2023.129350. Epub 2023 May 27. Bioorg Med Chem Lett. 2023. PMID: 37247697
Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML.
DeRatt LG, Zhang Z, Pietsch C, Cisar JS, Zhang X, Wang W, Tanner A, Matico R, Shaffer P, Jacoby E, Kazmi F, Shukla N, Bush TL, Patrick A, Philippar U, Attar R, Edwards JP, Kuduk SD. DeRatt LG, et al. Among authors: kuduk sd. J Med Chem. 2024 Jun 18. doi: 10.1021/acs.jmedchem.4c00809. Online ahead of print. J Med Chem. 2024. PMID: 38889244
Diazepinone HBV capsid assembly modulators.
Kuduk SD, DeRatt LG, Stoops B, Shaffer P, Lam AM, Espiritu C, Vogel R, Lau V, Flores OA, Hartman GD. Kuduk SD, et al. Bioorg Med Chem Lett. 2022 Sep 15;72:128823. doi: 10.1016/j.bmcl.2022.128823. Epub 2022 May 27. Bioorg Med Chem Lett. 2022. PMID: 35644301
Oxadiazepinone HBV capsid assembly modulators.
Kuduk SD, Stoops B, Lam AM, Espiritu C, Vogel R, Lau V, Klumpp K, Flores OA, Hartman GD. Kuduk SD, et al. Bioorg Med Chem Lett. 2021 Nov 15;52:128353. doi: 10.1016/j.bmcl.2021.128353. Epub 2021 Sep 4. Bioorg Med Chem Lett. 2021. PMID: 34492302
Identification of a new class of HBV capsid assembly modulator.
Kuduk SD, Stoops B, Alexander R, Lam AM, Espiritu C, Vogel R, Lau V, Klumpp K, Flores OA, Hartman GD. Kuduk SD, et al. Bioorg Med Chem Lett. 2021 May 1;39:127848. doi: 10.1016/j.bmcl.2021.127848. Epub 2021 Feb 18. Bioorg Med Chem Lett. 2021. PMID: 33610748
A carboxylic acid isostere screen of the DHODH inhibitor Brequinar.
DeRatt LG, Christine Pietsch E, Tanner A, Shaffer P, Jacoby E, Wang W, Kazmi F, Zhang X, Attar RM, Edwards JP, Kuduk SD. DeRatt LG, et al. Among authors: kuduk sd. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127589. doi: 10.1016/j.bmcl.2020.127589. Epub 2020 Sep 29. Bioorg Med Chem Lett. 2020. PMID: 33007394
85 results