Downs T - Search Results

1

Mitotic inhibition and aneuploidy induction by naturally occurring and synthetic estrogens in Chinese hamster cells in vitro.

Wheeler WJ, Cherry LM, Downs T, Hsu TC. Wheeler WJ, et al. Among authors: downs t. Mutat Res. 1986 Jul;171(1):31-41. doi: 10.1016/0165-1218(86)90006-6. Mutat Res. 1986. PMID: 3724781

2

Silica nanoparticles administered at the maximum tolerated dose induce genotoxic effects through an inflammatory reaction while gold nanoparticles do not.

Downs TR, Crosby ME, Hu T, Kumar S, Sullivan A, Sarlo K, Reeder B, Lynch M, Wagner M, Mills T, Pfuhler S. Downs TR, et al. Mutat Res. 2012 Jun 14;745(1-2):38-50. doi: 10.1016/j.mrgentox.2012.03.012. Epub 2012 Apr 6. Mutat Res. 2012. PMID: 22504169

3

Weak silica nanomaterial-induced genotoxicity can be explained by indirect DNA damage as shown by the OGG1-modified comet assay and genomic analysis.

Pfuhler S, Downs TR, Allemang AJ, Shan Y, Crosby ME. Pfuhler S, et al. Mutagenesis. 2017 Jan;32(1):5-12. doi: 10.1093/mutage/gew064. Epub 2016 Nov 17. Mutagenesis. 2017. PMID: 27864332

4

Validation of the 3D Skin Comet assay using full thickness skin models: Transferability and reproducibility.

Reisinger K, Blatz V, Brinkmann J, Downs TR, Fischer A, Henkler F, Hoffmann S, Krul C, Liebsch M, Luch A, Pirow R, Reus AA, Schulz M, Pfuhler S. Reisinger K, et al. Mutat Res Genet Toxicol Environ Mutagen. 2018 Mar;827:27-41. doi: 10.1016/j.mrgentox.2018.01.003. Epub 2018 Jan 10. Mutat Res Genet Toxicol Environ Mutagen. 2018. PMID: 29502735 Free article.

5

Effect of 2-acetylaminofluorene and its genotoxic metabolites on DNA adduct formation and DNA damage in 3D reconstructed human skin tissue models.

Downs TR, Arlt VM, Barnett BC, Posgai R, Pfuhler S. Downs TR, et al. Mutagenesis. 2021 Apr 28;36(1):63-74. doi: 10.1093/mutage/gez044. Mutagenesis. 2021. PMID: 31816077 Free PMC article.

6

Validation of the 3D reconstructed human skin micronucleus (RSMN) assay: an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays.

Pfuhler S, Downs TR, Hewitt NJ, Hoffmann S, Mun GC, Ouedraogo G, Roy S, Curren RD, Aardema MJ. Pfuhler S, et al. Mutagenesis. 2021 Apr 28;36(1):1-17. doi: 10.1093/mutage/geaa035. Mutagenesis. 2021. PMID: 33544138 Free PMC article.

7

Validation of the 3D reconstructed human skin Comet assay, an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays.

Pfuhler S, Pirow R, Downs TR, Haase A, Hewitt N, Luch A, Merkel M, Petrick C, Said A, Schäfer-Korting M, Reisinger K. Pfuhler S, et al. Mutagenesis. 2021 Apr 28;36(1):19-35. doi: 10.1093/mutage/geaa009. Mutagenesis. 2021. PMID: 32152633 Free PMC article.

8

Comet assay in reconstructed 3D human epidermal skin models--investigation of intra- and inter-laboratory reproducibility with coded chemicals.

Reus AA, Reisinger K, Downs TR, Carr GJ, Zeller A, Corvi R, Krul CA, Pfuhler S. Reus AA, et al. Mutagenesis. 2013 Nov;28(6):709-20. doi: 10.1093/mutage/get051. Mutagenesis. 2013. PMID: 24150594 Free PMC article.

9

Efficacy of Intravesical Nadofaragene Firadenovec for Patients With Bacillus Calmette-Guérin-Unresponsive Nonmuscle-Invasive Bladder Cancer: 5-Year Follow-Up From a Phase 3 Trial.

Narayan VM, Boorjian SA, Alemozaffar M, Konety BR, Shore ND, Gomella LG, Kamat AM, Bivalacqua TJ, Montgomery JS, Lerner SP, Busby JE, Poch M, Crispen PL, Steinberg GD, Schuckman AK, Downs TM, Mashni J Jr, Lane BR, Guzzo TJ, Bratslavsky G, Karsh LI, Woods ME, Brown G, Canter D, Luchey A, Lotan Y, Inman BA, Williams MB, Cookson MS, Chang SS, Sankin AI, O'Donnell MA, Sawutz D, Philipson R, Parker NR, Yla-Herttuala S, Rehm D, Jakobsen JS, Juul K, Dinney CPN. Narayan VM, et al. Among authors: downs tm. J Urol. 2024 Jul;212(1):74-86. doi: 10.1097/JU.0000000000004020. Epub 2024 May 5. J Urol. 2024. PMID: 38704840 Clinical Trial.

10

Impact of Triage Systems on Time to Diagnosis and Treatment of Traumatic Brain Injuries.

Nwizu M, Weiner T, Downs T, Krizo J, Mangira C, Cowan S, Mallat A, Heaney A. Nwizu M, et al. Among authors: downs t. J Emerg Med. 2024 Mar;66(3):e304-e312. doi: 10.1016/j.jemermed.2023.11.005. Epub 2023 Nov 10. J Emerg Med. 2024. PMID: 38429213

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