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A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations.
Allen SP, Al Sultan A, Kabucho Kibirige E, Tonkiss E, Hamer KJ, Castelli LM, Lin YH, Roscoe S, Stefanidis N, Mead RJ, Highley JR, Cooper-Knock J, Hautbergue GM, Heath PR, Kirby J, Shaw PJ. Allen SP, et al. Among authors: kabucho kibirige e. Front Aging Neurosci. 2023 May 11;15:1151848. doi: 10.3389/fnagi.2023.1151848. eCollection 2023. Front Aging Neurosci. 2023. PMID: 37251807 Free PMC article.