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Advanced age results in a diminished endothelial glycocalyx.
Machin DR, Bloom SI, Campbell RA, Phuong TTT, Gates PE, Lesniewski LA, Rondina MT, Donato AJ. Machin DR, et al. Among authors: bloom si. Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H531-H539. doi: 10.1152/ajpheart.00104.2018. Epub 2018 May 11. Am J Physiol Heart Circ Physiol. 2018. PMID: 29750566 Free PMC article.
Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress.
Morgan RG, Walker AE, Trott DW, Machin DR, Henson GD, Reihl KD, Cawthon RM, Denchi EL, Liu Y, Bloom SI, Phuong TT, Richardson RS, Lesniewski LA, Donato AJ. Morgan RG, et al. Among authors: bloom si. J Mol Cell Cardiol. 2019 Feb;127:74-82. doi: 10.1016/j.yjmcc.2018.11.014. Epub 2018 Nov 29. J Mol Cell Cardiol. 2019. PMID: 30502348 Free PMC article.
T cells mediate cell non-autonomous arterial ageing in mice.
Trott DW, Machin DR, Phuong TTT, Adeyemo AO, Bloom SI, Bramwell RC, Sorensen ES, Lesniewski LA, Donato AJ. Trott DW, et al. Among authors: bloom si. J Physiol. 2021 Aug;599(16):3973-3991. doi: 10.1113/JP281698. J Physiol. 2021. PMID: 34164826 Free PMC article.
Mechanisms and consequences of endothelial cell senescence.
Bloom SI, Islam MT, Lesniewski LA, Donato AJ. Bloom SI, et al. Nat Rev Cardiol. 2023 Jan;20(1):38-51. doi: 10.1038/s41569-022-00739-0. Epub 2022 Jul 19. Nat Rev Cardiol. 2023. PMID: 35853997 Free PMC article. Review.
Glycocalyx-targeted therapy ameliorates age-related arterial dysfunction.
Machin DR, Trott DW, Gogulamudi VR, Islam MT, Bloom SI, Vink H, Lesniewski LA, Donato AJ. Machin DR, et al. Among authors: bloom si. Geroscience. 2023 Aug;45(4):2351-2365. doi: 10.1007/s11357-023-00745-1. Epub 2023 Feb 14. Geroscience. 2023. PMID: 36787090 Free PMC article.
19 results