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Meta-omics profiling of the gut-lung axis illuminates metabolic networks and host-microbial interactions associated with elevated lung elastance in a murine model of obese allergic asthma.
Heinrich VA, Uvalle C, Manni ML, Li K, Mullett SJ, Donepudi SR, Clader J, Fitch A, Ellgass M, Cechova V, Qin S, Holguin F, Freeman BA, Methé BA, Morris A, Gelhaus SL. Heinrich VA, et al. Among authors: clader j. Front Microbiomes. 2023;2:1153691. doi: 10.3389/frmbi.2023.1153691. Epub 2023 May 5. Front Microbiomes. 2023. PMID: 37293566 Free PMC article.
Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors.
Zhao Z, Pissarnitski DA, Josien HB, Bara TA, Clader JW, Li H, McBriar MD, Rajagopalan M, Xu R, Terracina G, Hyde L, Song L, Zhang L, Parker EM, Osterman R, Buevich AV. Zhao Z, et al. Among authors: clader jw. Eur J Med Chem. 2016 Nov 29;124:36-48. doi: 10.1016/j.ejmech.2016.08.024. Epub 2016 Aug 13. Eur J Med Chem. 2016. PMID: 27560281
Discovery of a Novel, Potent Spirocyclic Series of γ-Secretase Inhibitors.
Zhao Z, Pissarnitski DA, Josien HB, Wu WL, Xu R, Li H, Clader JW, Burnett DA, Terracina G, Hyde L, Lee J, Song L, Zhang L, Parker EM. Zhao Z, et al. Among authors: clader jw. J Med Chem. 2015 Nov 25;58(22):8806-17. doi: 10.1021/acs.jmedchem.5b00774. Epub 2015 Nov 6. J Med Chem. 2015. PMID: 26496070
Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.
McKittrick BA, Caldwell JP, Bara T, Boykow G, Chintala M, Clader J, Czarniecki M, Courneya B, Duffy R, Fleming L, Giessert R, Greenlee WJ, Heap C, Hong L, Huang Y, Iserloh U, Josien H, Khan T, Korfmacher W, Liang X, Mazzola R, Mitra S, Moore K, Orth P, Rajagopalan M, Roy S, Sakwa S, Strickland C, Vaccaro H, Voigt J, Wang H, Wong J, Zhang R, Zych A. McKittrick BA, et al. Among authors: clader j. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1592-6. doi: 10.1016/j.bmcl.2015.02.003. Epub 2015 Feb 10. Bioorg Med Chem Lett. 2015. PMID: 25728416
In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects.
Hyde LA, Zhang Q, Del Vecchio RA, Leach PT, Cohen-Williams ME, Chen L, Wong GT, McHugh NA, Chen J, Higgins GA, Asberom T, Li W, Pissarnitski D, Levitan D, Nomeir AA, Clader JW, Zhang L, Parker EM. Hyde LA, et al. Among authors: clader jw. Int J Alzheimers Dis. 2013;2013:823528. doi: 10.1155/2013/823528. Epub 2013 Mar 14. Int J Alzheimers Dis. 2013. PMID: 23573456 Free PMC article.
Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors.
Wu WL, Asberom T, Bara T, Bennett C, Burnett DA, Clader J, Domalski M, Greenlee WJ, Josien H, McBriar M, Rajagopalan M, Vicarel M, Xu R, Hyde LA, Del Vecchio RA, Cohen-Williams ME, Song L, Lee J, Terracina G, Zhang Q, Nomeir A, Parker EM, Zhang L. Wu WL, et al. Among authors: clader j. Bioorg Med Chem Lett. 2013 Feb 1;23(3):844-9. doi: 10.1016/j.bmcl.2012.11.047. Epub 2012 Nov 24. Bioorg Med Chem Lett. 2013. PMID: 23265892
The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease.
Li H, Qin J, Dhondi P, Zhou W, Vicarel M, Bara T, Cole D, Josien H, Pissarnitski D, Zhu Z, Palani A, Aslanian R, Clader J, Czarniecki M, Greenlee W, Cohen-Williams M, Hyde L, Song L, Zhang L, Chu I, Huang X. Li H, et al. Among authors: clader j. Bioorg Med Chem Lett. 2013 Jan 15;23(2):466-71. doi: 10.1016/j.bmcl.2012.11.055. Epub 2012 Nov 29. Bioorg Med Chem Lett. 2013. PMID: 23253441
75 results