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Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis.
Povero D, Lazic M, McBride C, Ambrus-Aikelin G, Stansfield R, Johnson CD, Santini AM, Pranadinata RF, McGeough MD, Stafford JA, Hoffman HM, Feldstein AE, Veal JM, Bain G. Povero D, et al. Among authors: bain g. J Pharmacol Exp Ther. 2023 Aug;386(2):242-258. doi: 10.1124/jpet.123.001639. Epub 2023 Jun 12. J Pharmacol Exp Ther. 2023. PMID: 37308266
Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor.
McBride C, Trzoss L, Povero D, Lazic M, Ambrus-Aikelin G, Santini A, Pranadinata R, Bain G, Stansfield R, Stafford JA, Veal J, Takahashi R, Ly J, Chen S, Liu L, Nespi M, Blake R, Katewa A, Kleinheinz T, Sujatha-Bhaskar S, Ramamoorthi N, Sims J, McKenzie B, Chen M, Ultsch M, Johnson M, Murray J, Ciferri C, Staben ST, Townsend MJ, Stivala CE. McBride C, et al. Among authors: bain g. J Med Chem. 2022 Nov 10;65(21):14721-14739. doi: 10.1021/acs.jmedchem.2c01250. Epub 2022 Oct 24. J Med Chem. 2022. PMID: 36279149
JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.
Ambrus-Aikelin G, Takeda K, Joetham A, Lazic M, Povero D, Santini AM, Pranadinata R, Johnson CD, McGeough MD, Beasley FC, Stansfield R, McBride C, Trzoss L, Hoffman HM, Feldstein AE, Stafford JA, Veal JM, Bain G, Gelfand EW. Ambrus-Aikelin G, et al. Among authors: bain g. Sci Rep. 2023 Aug 19;13(1):13524. doi: 10.1038/s41598-023-39805-z. Sci Rep. 2023. PMID: 37598239 Free PMC article.
Author Correction: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.
Ambrus-Aikelin G, Takeda K, Joetham A, Lazic M, Povero D, Santini AM, Pranadinata R, Johnson CD, McGeough MD, Beasley FC, Stansfield R, McBride C, Trzoss L, Hoffman HM, Feldstein AE, Stafford JA, Veal JM, Bain G, Gelfand EW. Ambrus-Aikelin G, et al. Among authors: bain g. Sci Rep. 2023 Nov 16;13(1):20081. doi: 10.1038/s41598-023-47251-0. Sci Rep. 2023. PMID: 37973811 Free PMC article. No abstract available.
Classification of elbow stiffness.
Marinelli A, Guerra E, Bain G. Marinelli A, et al. Among authors: bain g. J ISAKOS. 2024 Apr;9(2):234-239. doi: 10.1016/j.jisako.2023.10.011. Epub 2023 Nov 2. J ISAKOS. 2024. PMID: 37923144 Free article.
British Society of Gastroenterology interim framework for addressing the COVID-19-related backlog in inflammatory bowel disease colorectal cancer surveillance.
Churchhouse AM, Moffat VE, Selinger CP, Lamb CA, Thornton MJ, Penman I, Din S; BSG and Scottish IBD Surveillance Group; BSG, Scottish IBD Surveillance Group. Churchhouse AM, et al. Gut. 2023 Sep;72(9):1631-1634. doi: 10.1136/gutjnl-2022-328309. Epub 2022 Sep 5. Gut. 2023. PMID: 37549983 Free PMC article. No abstract available.
Interdisciplinary consensus statements on imaging of DRUJ instability and TFCC injuries.
Cerezal L, Del Piñal F, Atzei A, Schmitt R, Becce F, Klich M, Bień M, de Jonge MC, Teh J, Boutin RD, Toms AP, Omoumi P, Fritz J, Bazzocchi A, Shahabpour M, Zanetti M, Llopis E, Blum A, Lalam RK, Reto S, Afonso PD, Mascarenhas VV, Cotten A, Drapé JL, Bierry G, Pracoń G, Dalili D, Mespreuve M, Garcia-Elias M, Bain GI, Mathoulin CL, Van Overstraeten L, Szabo RM, Camus EJ, Luchetti R, Chojnowski AJ, Gruenert JG, Czarnecki P, Corella F, Nagy L, Yamamoto M, Golubev IO, van Schoonhoven J, Goehtz F, Sudoł-Szopińska I, Dietrich TJ. Cerezal L, et al. Among authors: bain gi. Eur Radiol. 2023 Sep;33(9):6322-6338. doi: 10.1007/s00330-023-09698-7. Epub 2023 May 16. Eur Radiol. 2023. PMID: 37191922
Scaphoid kinematics in scapholunate instability: a dynamic CT study.
Amarasooriya M, Al-Dirini R, Bryant K, Bain GI. Amarasooriya M, et al. Among authors: bain gi. Skeletal Radiol. 2023 Aug;52(8):1557-1566. doi: 10.1007/s00256-023-04323-6. Epub 2023 Mar 23. Skeletal Radiol. 2023. PMID: 36951995 Free PMC article.
362 results