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Dose-dependent effects of GAT107, a novel allosteric agonist-positive allosteric modulator (ago-PAM) for the α7 nicotinic cholinergic receptor: a BOLD phMRI and connectivity study on awake rats.
Front Neurosci. 2023 Jun 23;17:1196786. doi: 10.3389/fnins.2023.1196786. eCollection 2023.
Front Neurosci. 2023.
PMID: 37424993
Free PMC article.
Design and Characterization of Immune-Stimulating Imidazo[4,5-c]quinoline Antibody-Drug Conjugates.
Fang S, Brems BM, Olawode EO, Miller JT, Brooks TA, Tumey LN.
Fang S, et al. Among authors: brems bm.
Mol Pharm. 2022 Sep 5;19(9):3228-3241. doi: 10.1021/acs.molpharmaceut.2c00392. Epub 2022 Jul 29.
Mol Pharm. 2022.
PMID: 35904247
Free PMC article.
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Evaluation of an ester-linked immunosuppressive payload: A case study in understanding the stability and cleavability of ester-containing ADC linkers.
Jackson CP, Fang S, Benjamin SR, Alayi T, Hathout Y, Gillen SM, Handel JP, Brems BM, Howe JM, Tumey LN.
Jackson CP, et al. Among authors: brems bm.
Bioorg Med Chem Lett. 2022 Nov 1;75:128953. doi: 10.1016/j.bmcl.2022.128953. Epub 2022 Sep 1.
Bioorg Med Chem Lett. 2022.
PMID: 36058468
Free PMC article.
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Conformationally Selective 2-Aminotetralin Ligands Targeting the alpha2A- and alpha2C-Adrenergic Receptors.
Fragola NR, Brems BM, Mukherjee M, Cui M, Booth RG.
Fragola NR, et al. Among authors: brems bm.
ACS Chem Neurosci. 2023 May 17;14(10):1884-1895. doi: 10.1021/acschemneuro.3c00148. Epub 2023 Apr 27.
ACS Chem Neurosci. 2023.
PMID: 37104867
Free PMC article.
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Expanding the Versatility of Microbial Transglutaminase Using α-Effect Nucleophiles as Noncanonical Substrates.
Chio TI, Demestichas BR, Brems BM, Bane SL, Tumey LN.
Chio TI, et al. Among authors: brems bm.
Angew Chem Int Ed Engl. 2020 Aug 10;59(33):13814-13820. doi: 10.1002/anie.202001830. Epub 2020 Jun 3.
Angew Chem Int Ed Engl. 2020.
PMID: 32268004
Free PMC article.
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