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Ldlr-/-.Leiden mice develop neurodegeneration, age-dependent astrogliosis and obesity-induced changes in microglia immunophenotype which are partly reversed by complement component 5 neutralizing antibody.
Seidel F, Fluiter K, Kleemann R, Worms N, van Nieuwkoop A, Caspers MPM, Grigoriadis N, Kiliaan AJ, Baas F, Michailidou I, Morrison MC. Seidel F, et al. Among authors: fluiter k. Front Cell Neurosci. 2023 Jun 29;17:1205261. doi: 10.3389/fncel.2023.1205261. eCollection 2023. Front Cell Neurosci. 2023. PMID: 37457817 Free PMC article.
Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis.
Michailidou I, Jongejan A, Vreijling JP, Georgakopoulou T, de Wissel MB, Wolterman RA, Ruizendaal P, Klar-Mohamad N, Grootemaat AE, Picavet DI, Kumar V, van Kooten C, Woodruff TM, Morgan BP, van der Wel NN, Ramaglia V, Fluiter K, Baas F. Michailidou I, et al. Among authors: fluiter k. Acta Neuropathol Commun. 2018 May 3;6(1):36. doi: 10.1186/s40478-018-0536-y. Acta Neuropathol Commun. 2018. PMID: 29724241 Free PMC article.
Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex.
Gytz Olesen H, Michailidou I, Zelek WM, Vreijling J, Ruizendaal P, de Klein F, Marquart JA, Kuipers TB, Mei H, Zhang Y, Ahasan M, Johnson KK, Wang Y, Morgan BP, van Dijk M, Fluiter K, Andersen GR, Baas F. Gytz Olesen H, et al. Among authors: fluiter k. J Innate Immun. 2023;15(1):16-36. doi: 10.1159/000524587. Epub 2022 May 12. J Innate Immun. 2023. PMID: 35551129 Free PMC article.
Therapeutic Intervention with Anti-Complement Component 5 Antibody Does Not Reduce NASH but Does Attenuate Atherosclerosis and MIF Concentrations in Ldlr-/-.Leiden Mice.
Seidel F, Kleemann R, van Duyvenvoorde W, van Trigt N, Keijzer N, van der Kooij S, van Kooten C, Verschuren L, Menke A, Kiliaan AJ, Winter J, Hughes TR, Morgan BP, Baas F, Fluiter K, Morrison MC. Seidel F, et al. Among authors: fluiter k. Int J Mol Sci. 2022 Sep 14;23(18):10736. doi: 10.3390/ijms231810736. Int J Mol Sci. 2022. PMID: 36142647 Free PMC article.
The systemic inhibition of the terminal complement system reduces neuroinflammation but does not improve motor function in mouse models of CMT1A with overexpressed PMP22.
Michailidou I, Vreijling J, Rumpf M, Loos M, Koopmans B, Vlek N, Straat N, Agaser C, Kuipers TB, Mei H, Baas F, Fluiter K. Michailidou I, et al. Among authors: fluiter k. Curr Res Neurobiol. 2023 Feb 4;4:100077. doi: 10.1016/j.crneur.2023.100077. eCollection 2023. Curr Res Neurobiol. 2023. PMID: 36926597 Free PMC article.
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