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ent -Verticilide B1 inhibits type 2 ryanodine receptor channels and is antiarrhythmic in Casq2-/- mice.
Gochman A, Do TQ, Kim K, Schwarz JA, Thorpe MP, Blackwell DJ, Smith AN, Akers WS, Cornea RL, Laver DR, Johnston JN, Knollmann BC. Gochman A, et al. Among authors: laver dr. bioRxiv [Preprint]. 2023 Jul 5:2023.07.03.547578. doi: 10.1101/2023.07.03.547578. bioRxiv. 2023. Update in: Mol Pharmacol. 2024 Feb 15;105(3):194-201. doi: 10.1124/molpharm.123.000752. PMID: 37461611 Free PMC article. Updated. Preprint.
A bivalent remipede toxin promotes calcium release via ryanodine receptor activation.
Maxwell MJ, Thekkedam C, Lamboley C, Chin YK, Crawford T, Smith JJ, Liu J, Jia X, Vetter I, Laver DR, Launikonis BS, Dulhunty A, Undheim EAB, Mobli M. Maxwell MJ, et al. Among authors: laver dr. Nat Commun. 2023 Feb 23;14(1):1036. doi: 10.1038/s41467-023-36579-w. Nat Commun. 2023. PMID: 36823422 Free PMC article.
Mammalian TRP ion channels are insensitive to membrane stretch.
Nikolaev YA, Cox CD, Ridone P, Rohde PR, Cordero-Morales JF, Vásquez V, Laver DR, Martinac B. Nikolaev YA, et al. Among authors: laver dr. J Cell Sci. 2019 Dec 10;132(23):jcs238360. doi: 10.1242/jcs.238360. J Cell Sci. 2019. PMID: 31722978 Free PMC article.
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia.
Ottesen AH, Carlson CR, Eken OS, Sadredini M, Myhre PL, Shen X, Dalhus B, Laver DR, Lunde PK, Kurola J, Lunde M, Hoff JE, Godang K, Sjaastad I, Pettilä V, Stridsberg M, Lehnart SE, Edwards AG, Lunde IG, Omland T, Stokke MK, Christensen G, Røsjø H, Louch WE. Ottesen AH, et al. Among authors: laver dr. Circ Arrhythm Electrophysiol. 2019 Apr;12(4):e007045. doi: 10.1161/CIRCEP.118.007045. Circ Arrhythm Electrophysiol. 2019. PMID: 30943765 Free article.
79 results