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Development of new thiazolidine-2,4-dione hybrids as aldose reductase inhibitors endowed with antihyperglycaemic activity: design, synthesis, biological investigations, and in silico insights.
J Enzyme Inhib Med Chem. 2023 Dec;38(1):2231170. doi: 10.1080/14756366.2023.2231170.
J Enzyme Inhib Med Chem. 2023.
PMID: 37470409
Free PMC article.
New benzothiazole hybrids as potential VEGFR-2 inhibitors: design, synthesis, anticancer evaluation, and in silico study.
Al-Sanea MM, Hamdi A, Mohamed AAB, El-Shafey HW, Moustafa M, Elgazar AA, Eldehna WM, Ur Rahman H, Parambi DGT, Elbargisy RM, Selim S, Bukhari SNA, Magdy Hendawy O, Tawfik SS.
Al-Sanea MM, et al. Among authors: el shafey hw.
J Enzyme Inhib Med Chem. 2023 Dec;38(1):2166036. doi: 10.1080/14756366.2023.2166036.
J Enzyme Inhib Med Chem. 2023.
PMID: 36691927
Free PMC article.
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Design, synthesis, antitumor, and VEGFR-2 inhibition activities of novel 4-anilino-2-vinyl-quinazolines: Molecular modeling studies.
Hamdi A, El-Shafey HW, Othman DIA, El-Azab AS, AlSaif NA, Abdel-Aziz AA.
Hamdi A, et al. Among authors: el shafey hw.
Bioorg Chem. 2022 May;122:105710. doi: 10.1016/j.bioorg.2022.105710. Epub 2022 Mar 1.
Bioorg Chem. 2022.
PMID: 35278776
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Quinazoline Based HSP90 Inhibitors: Synthesis, Modeling Study and ADME Calculations Towards Breast Cancer Targeting.
El-Shafey HW, Gomaa RM, El-Messery SM, Goda FE.
El-Shafey HW, et al.
Bioorg Med Chem Lett. 2020 Aug 1;30(15):127281. doi: 10.1016/j.bmcl.2020.127281. Epub 2020 May 21.
Bioorg Med Chem Lett. 2020.
PMID: 32527460
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Synthetic approaches, anticancer potential, HSP90 inhibition, multitarget evaluation, molecular modeling and apoptosis mechanistic study of thioquinazolinone skeleton: Promising antibreast cancer agent.
El-Shafey HW, Gomaa RM, El-Messery SM, Goda FE.
El-Shafey HW, et al.
Bioorg Chem. 2020 Aug;101:103987. doi: 10.1016/j.bioorg.2020.103987. Epub 2020 Jun 1.
Bioorg Chem. 2020.
PMID: 32540783
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