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C910 chemical compound inhibits the traffiking of several bacterial AB toxins with cross-protection against influenza virus.
Wu Y, Mahtal N, Paillares E, Swistak L, Sagadiev S, Acharya M, Demeret C, Werf SV, Guivel-Benhassine F, Schwartz O, Petracchini S, Mettouchi A, Caramelle L, Couvineau P, Thai R, Barbe P, Keck M, Brodin P, Machelart A, Sencio V, Trottein F, Sachse M, Chicanne G, Payrastre B, Ville F, Kreis V, Popoff MR, Johannes L, Cintrat JC, Barbier J, Gillet D, Lemichez E. Wu Y, et al. Among authors: couvineau p. iScience. 2022 Jun 6;25(7):104537. doi: 10.1016/j.isci.2022.104537. eCollection 2022 Jul 15. iScience. 2022. PMID: 35769882 Free PMC article.
Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects.
Tran K, Sainsily X, Côté J, Coquerel D, Couvineau P, Saibi S, Haroune L, Besserer-Offroy É, Flynn-Robitaille J, Resua Rojas M, Murza A, Longpré JM, Auger-Messier M, Lesur O, Bouvier M, Marsault É, Boudreault PL, Sarret P. Tran K, et al. Among authors: couvineau p. J Med Chem. 2022 Jan 13;65(1):531-551. doi: 10.1021/acs.jmedchem.1c01708. Epub 2022 Jan 4. J Med Chem. 2022. PMID: 34982553
Ackr3-Venus knock-in mouse lights up brain vasculature.
Ehrlich AT, Semache M, Couvineau P, Wojcik S, Kobayashi H, Thelen M, Gross F, Hogue M, Le Gouill C, Darcq E, Bouvier M, Kieffer BL. Ehrlich AT, et al. Among authors: couvineau p. Mol Brain. 2021 Sep 28;14(1):151. doi: 10.1186/s13041-021-00862-y. Mol Brain. 2021. PMID: 34583741 Free PMC article.
Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile.
Trân K, Van Den Hauwe R, Sainsily X, Couvineau P, Côté J, Simard L, Echevarria M, Murza A, Serre A, Théroux L, Saibi S, Haroune L, Longpré JM, Lesur O, Auger-Messier M, Spino C, Bouvier M, Sarret P, Ballet S, Marsault É. Trân K, et al. Among authors: couvineau p. J Med Chem. 2021 May 13;64(9):5345-5364. doi: 10.1021/acs.jmedchem.0c01941. Epub 2021 Feb 1. J Med Chem. 2021. PMID: 33524256
16 results