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Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity.
Dichiara M, Ambrosio FA, Lee SM, Ruiz-Cantero MC, Lombino J, Coricello A, Costa G, Shah D, Costanzo G, Pasquinucci L, Son KN, Cosentino G, González-Cano R, Marrazzo A, Aakalu VK, Cobos EJ, Alcaro S, Amata E. Dichiara M, et al. Among authors: cobos ej. J Med Chem. 2023 Aug 24;66(16):11447-11463. doi: 10.1021/acs.jmedchem.3c00959. Epub 2023 Aug 3. J Med Chem. 2023. PMID: 37535861 Free PMC article.
Tetrodotoxin (TTX) as a therapeutic agent for pain.
Nieto FR, Cobos EJ, Tejada MÁ, Sánchez-Fernández C, González-Cano R, Cendán CM. Nieto FR, et al. Among authors: cobos ej. Mar Drugs. 2012 Feb;10(2):281-305. doi: 10.3390/md10020281. Epub 2012 Jan 31. Mar Drugs. 2012. PMID: 22412801 Free PMC article. Review.
Potentiation of morphine-induced mechanical antinociception by σ₁ receptor inhibition: role of peripheral σ₁ receptors.
Sánchez-Fernández C, Nieto FR, González-Cano R, Artacho-Cordón A, Romero L, Montilla-García Á, Zamanillo D, Baeyens JM, Entrena JM, Cobos EJ. Sánchez-Fernández C, et al. Among authors: cobos ej. Neuropharmacology. 2013 Jul;70:348-58. doi: 10.1016/j.neuropharm.2013.03.002. Epub 2013 Mar 21. Neuropharmacology. 2013. PMID: 23524304
Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice.
Tejada MA, Montilla-García A, Cronin SJ, Cikes D, Sánchez-Fernández C, González-Cano R, Ruiz-Cantero MC, Penninger JM, Vela JM, Baeyens JM, Cobos EJ. Tejada MA, et al. Among authors: cobos ej. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8396-8401. doi: 10.1073/pnas.1620068114. Epub 2017 Jul 17. Proc Natl Acad Sci U S A. 2017. PMID: 28716934 Free PMC article.
(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties.
Amata E, Rescifina A, Prezzavento O, Arena E, Dichiara M, Pittalà V, Montilla-García Á, Punzo F, Merino P, Cobos EJ, Marrazzo A. Amata E, et al. Among authors: cobos ej. J Med Chem. 2018 Jan 11;61(1):372-384. doi: 10.1021/acs.jmedchem.7b01584. Epub 2017 Dec 20. J Med Chem. 2018. PMID: 29220177
60 results