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Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity.
Dichiara M, Ambrosio FA, Lee SM, Ruiz-Cantero MC, Lombino J, Coricello A, Costa G, Shah D, Costanzo G, Pasquinucci L, Son KN, Cosentino G, González-Cano R, Marrazzo A, Aakalu VK, Cobos EJ, Alcaro S, Amata E. Dichiara M, et al. Among authors: marrazzo a. J Med Chem. 2023 Aug 24;66(16):11447-11463. doi: 10.1021/acs.jmedchem.3c00959. Epub 2023 Aug 3. J Med Chem. 2023. PMID: 37535861 Free PMC article.
Synthesis of (+)-(1'R,2'S) and (1'S,2'R)-6,11-dimethyl-1,2,3,4,5,6 -hexahydro-3-[[2'-(alkoxycarbonyl)-2'-phenylcyclopropyl]methyl]-2 ,6 -methano-3-benzazocin-8-ol. Comparison of the affinities for sigma 1 and opioid receptors with in the diastereoisomeric MPCB and CCB.
Ronsisvalle G, Prezzavento O, Pasquinucci L, Pappalardo MS, Marrazzo A, Vittorio F, Carboni L, Spampinato S. Ronsisvalle G, et al. Among authors: marrazzo a. Farmaco. 1997 Jun-Jul;52(6-7):471-6. Farmaco. 1997. PMID: 9372600
Specific kappa opioid receptor agonists.
Ronsisvalle G, Marrazzo A, Pasquinucci L, Prezzavento O, Pappalardo M, Vittorio F. Ronsisvalle G, et al. Among authors: marrazzo a. Farmaco. 2001 Jan-Feb;56(1-2):121-5. doi: 10.1016/s0014-827x(01)01022-9. Farmaco. 2001. PMID: 11347952
Novel sigma receptor ligands: synthesis and biological profile.
Prezzavento O, Campisi A, Ronsisvalle S, Li Volti G, Marrazzo A, Bramanti V, Cannavò G, Vanella L, Cagnotto A, Mennini T, Ientile R, Ronsisvalle G. Prezzavento O, et al. Among authors: marrazzo a. J Med Chem. 2007 Mar 8;50(5):951-61. doi: 10.1021/jm0611197. Epub 2007 Feb 13. J Med Chem. 2007. PMID: 17328523
189 results