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Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting.
Lee EHJ, Murad JP, Christian L, Gibson J, Yamaguchi Y, Cullen C, Gumber D, Park AK, Young C, Monroy I, Yang J, Stern LA, Adkins LN, Dhapola G, Gittins B, Chang WC, Martinez C, Woo Y, Cristea M, Rodriguez-Rodriguez L, Ishihara J, Lee JK, Forman SJ, Wang LD, Priceman SJ. Lee EHJ, et al. Among authors: martinez c. Nat Commun. 2023 Aug 7;14(1):4737. doi: 10.1038/s41467-023-40115-1. Nat Commun. 2023. PMID: 37550294 Free PMC article.
Pre-conditioning modifies the TME to enhance solid tumor CAR T cell efficacy and endogenous protective immunity.
Murad JP, Tilakawardane D, Park AK, Lopez LS, Young CA, Gibson J, Yamaguchi Y, Lee HJ, Kennewick KT, Gittins BJ, Chang WC, Tran CP, Martinez C, Wu AM, Reiter RE, Dorff TB, Forman SJ, Priceman SJ. Murad JP, et al. Among authors: martinez c. Mol Ther. 2021 Jul 7;29(7):2335-2349. doi: 10.1016/j.ymthe.2021.02.024. Epub 2021 Feb 27. Mol Ther. 2021. PMID: 33647456 Free PMC article.
Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting.
Jun Lee EH, Cullen C, Murad JP, Gumber D, Park AK, Yang J, Stern LA, Adkins LN, Dhapola G, Gittins B, Chung-Chang W, Martinez C, Woo Y, Cristea M, Rodriguez-Rodriguez L, Ishihara J, Lee JK, Forman SJ, Wang LD, Priceman SJ. Jun Lee EH, et al. Among authors: martinez c. bioRxiv [Preprint]. 2023 Jan 7:2023.01.06.522784. doi: 10.1101/2023.01.06.522784. bioRxiv. 2023. Update in: Nat Commun. 2023 Aug 7;14(1):4737. doi: 10.1038/s41467-023-40115-1. PMID: 36711615 Free PMC article. Updated. Preprint.
PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trial.
Dorff TB, Blanchard MS, Adkins LN, Luebbert L, Leggett N, Shishido SN, Macias A, Del Real MM, Dhapola G, Egelston C, Murad JP, Rosa R, Paul J, Chaudhry A, Martirosyan H, Gerdts E, Wagner JR, Stiller T, Tilakawardane D, Pal S, Martinez C, Reiter RE, Budde LE, D'Apuzzo M, Kuhn P, Pachter L, Forman SJ, Priceman SJ. Dorff TB, et al. Among authors: martinez c. Nat Med. 2024 Jun;30(6):1636-1644. doi: 10.1038/s41591-024-02979-8. Epub 2024 Jun 12. Nat Med. 2024. PMID: 38867077 Free PMC article. Clinical Trial.
4,185 results