Synthetic Genetic Interaction (CRISPR-SGI) Profiling in Caenorhabditis elegans.
Calarco JA, Norris AD.
Calarco JA, et al. Among authors: norris ad.
Bio Protoc. 2018 Mar 5;8(5):e2756. doi: 10.21769/BioProtoc.2756.
Bio Protoc. 2018.
PMID: 29552597
Free PMC article.
Such studies have been performed to great effect in single-cell organisms such as yeast and E. coli (Schuldiner et al., 2005; Butland et al., 2008; Costanzo et al., 2010), but similar large-scale interaction studies using targeted reverse-genetic deletions in multi-cellular organ …
Such studies have been performed to great effect in single-cell organisms such as yeast and E. coli (Schuldiner et al., 2005; Butland et al. …