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Structure-Activity Relationship Studies of 2,4,5-Trisubstituted Pyrimidine Derivatives Leading to the Identification of a Novel and Potent Sirtuin 5 Inhibitor against Sepsis-Associated Acute Kidney Injury.
Mou L, Yang L, Hou S, Wang B, Wang X, Hu L, Deng J, Liu J, Chen X, Jiang Y, Zhang W, Lei P, Wang L, Li R, Fu P, Li GB, Ma L, Yang L. Mou L, et al. Among authors: chen x. J Med Chem. 2023 Aug 24;66(16):11517-11535. doi: 10.1021/acs.jmedchem.3c01031. Epub 2023 Aug 9. J Med Chem. 2023. PMID: 37556731
Discovery of a new class of ghrelin receptor antagonists.
Mihalic JT, Kim YJ, Lizarzaburu M, Chen X, Deignan J, Wanska M, Yu M, Fu J, Chen X, Zhang A, Connors R, Liang L, Lindstrom M, Ma J, Tang L, Dai K, Li L. Mihalic JT, et al. Among authors: chen x. Bioorg Med Chem Lett. 2012 Mar 1;22(5):2046-51. doi: 10.1016/j.bmcl.2012.01.014. Epub 2012 Jan 14. Bioorg Med Chem Lett. 2012. PMID: 22305493
Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production.
Du X, Moore J, Blank BR, Eksterowicz J, Sutimantanapi D, Yuen N, Metzger T, Chan B, Huang T, Chen X, Chen Y, Duong F, Kong W, Chang JH, Sun J, Zavorotinskaya T, Ye Q, Junttila MR, Ndubaku C, Friedman LS, Fantin VR, Sun D. Du X, et al. Among authors: chen x, chen y. J Med Chem. 2020 Sep 24;63(18):10433-10459. doi: 10.1021/acs.jmedchem.0c01086. Epub 2020 Sep 9. J Med Chem. 2020. PMID: 32865411
Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes.
Du X, Kim YJ, Lai S, Chen X, Lizarzaburu M, Turcotte S, Fu Z, Liu Q, Zhang Y, Motani A, Oda K, Okuyama R, Nara F, Murakoshi M, Fu A, Reagan JD, Fan P, Xiong Y, Shen W, Li L, Houze J, Medina JC. Du X, et al. Among authors: chen x. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6218-23. doi: 10.1016/j.bmcl.2012.08.015. Epub 2012 Aug 10. Bioorg Med Chem Lett. 2012. PMID: 22926069
Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633).
Du X, Eksterowicz J, Zhou H, Rew Y, Zhu L, Yan X, Medina JC, Huang T, Chen X, Sutimantanapi D, Jahchan N, Kong W, Sun J, Zavorotinskaya T, Ye Q, Fantin VR, Sun D. Du X, et al. Among authors: chen x. J Med Chem. 2019 Jul 25;62(14):6751-6764. doi: 10.1021/acs.jmedchem.9b00711. Epub 2019 Jul 5. J Med Chem. 2019. PMID: 31274313
108,428 results
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