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Activation of Munc13-1 by Diacylglycerol (DAG)-Lactones.
Das J, You Y, Mathukumalli K, Ann J, Lee J, Marquez VE. Das J, et al. Among authors: lee j. Biochemistry. 2023 Sep 19;62(18):2717-2726. doi: 10.1021/acs.biochem.3c00375. Epub 2023 Aug 31. Biochemistry. 2023. PMID: 37651159
Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha.
Garcia-Bermejo ML, Leskow FC, Fujii T, Wang Q, Blumberg PM, Ohba M, Kuroki T, Han KC, Lee J, Marquez VE, Kazanietz MG. Garcia-Bermejo ML, et al. Among authors: lee j. J Biol Chem. 2002 Jan 4;277(1):645-55. doi: 10.1074/jbc.M107639200. Epub 2001 Oct 2. J Biol Chem. 2002. PMID: 11584014 Free article.
Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain.
Choi Y, Kang JH, Lewin NE, Blumberg PM, Lee J, Marquez VE. Choi Y, et al. Among authors: lee j. J Med Chem. 2003 Jun 19;46(13):2790-3. doi: 10.1021/jm030082c. J Med Chem. 2003. PMID: 12801241
The structures of N-hydroxylamides 1a and 1b, previously reported by Lee et al. in J. Med. Chem. 2001, 44, 4309-4312 as strong protein kinase C (PK-C) ligands, were incorrect and correspond instead to esters 2a and 2b, respectively. ...
The structures of N-hydroxylamides 1a and 1b, previously reported by Lee et al. in J. Med. Chem. 2001, 44, 4309-4312 as strong …
Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities.
Duan D, Sigano DM, Kelley JA, Lai CC, Lewin NE, Kedei N, Peach ML, Lee J, Abeyweera TP, Rotenberg SA, Kim H, Kim YH, El Kazzouli S, Chung JU, Young HA, Young MR, Baker A, Colburn NH, Haimovitz-Friedman A, Truman JP, Parrish DA, Deschamps JR, Perry NA, Surawski RJ, Blumberg PM, Marquez VE. Duan D, et al. Among authors: lee j. J Med Chem. 2008 Sep 11;51(17):5198-220. doi: 10.1021/jm8001907. Epub 2008 Aug 13. J Med Chem. 2008. PMID: 18698758 Free PMC article.
The SAR analysis of TRPV1 agonists with the α-methylated B-region.
Cho Y, Kim MS, Kim HS, Ann J, Lee J, Pearce LV, Pavlyukovets VA, Morgan MA, Blumberg PM, Lee J. Cho Y, et al. Among authors: lee j. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5227-31. doi: 10.1016/j.bmcl.2012.06.059. Epub 2012 Jun 23. Bioorg Med Chem Lett. 2012. PMID: 22796184 Free PMC article.
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