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DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-β deposition in Alzheimer's disease The Ohio State University College of Medicine.
Daily KP, Badr A, Eltobgy M, Estfanous S, Whitham O, Tan MH, Carafice C, Krause K, McNamara A, Hamilton K, Houle S, Gupta S, Gupta GA, Madhu S, Fitzgerald J, Saadey AA, Laster B, Yan P, Webb A, Zhang X, Pietrzak M, Kokiko-Cochran ON, Ghoneim HE, Amer AO. Daily KP, et al. Among authors: ghoneim he. bioRxiv [Preprint]. 2023 Sep 1:2023.08.30.555526. doi: 10.1101/2023.08.30.555526. bioRxiv. 2023. PMID: 37693600 Free PMC article. Preprint.
DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer's disease.
Daily KP, Badr A, Eltobgy M, Estfanous S, Whitham O, Tan MH, Carafice C, Krause K, McNamara A, Hamilton K, Houle S, Gupta S, Gupta GA, Madhu S, Fitzgerald J, Saadey AA, Laster B, Yan P, Webb A, Zhang X, Pietrzak M, Kokiko-Cochran ON, Ghoneim HE, Amer AO. Daily KP, et al. Among authors: ghoneim he. Alzheimers Res Ther. 2024 Feb 8;16(1):29. doi: 10.1186/s13195-024-01390-2. Alzheimers Res Ther. 2024. PMID: 38326859 Free PMC article.
Microglia-targeted inhibition of miR-17 via mannose-coated lipid nanoparticles improves pathology and behavior in a mouse model of Alzheimer's disease.
Badr A, Daily KP, Eltobgy M, Estfanous S, Tan MH, Chun-Tien Kuo J, Whitham O, Carafice C, Gupta G, Amer HM, Shamseldin MM, Yousif A, Deems NP, Fitzgerald J, Yan P, Webb A, Zhang X, Pietrzak M, Ghoneim HE, Dubey P, Barrientos RM, Lee RJ, Kokiko-Cochran ON, Amer AO. Badr A, et al. Among authors: ghoneim he. Brain Behav Immun. 2024 May 7;119:919-944. doi: 10.1016/j.bbi.2024.05.006. Online ahead of print. Brain Behav Immun. 2024. PMID: 38718909 Free article.
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity.
Read KA, Jones DM, Pokhrel S, Hales EDS, Varkey A, Tuazon JA, Eisele CD, Abdouni O, Saadey A, Leonard MR, Warren RT, Powell MD, Boss JM, Hemann EA, Yount JS, Xin G, Ghoneim HE, Lio CJ, Freud AG, Collins PL, Oestreich KJ. Read KA, et al. Among authors: ghoneim he. Nat Commun. 2023 Mar 24;14(1):1652. doi: 10.1038/s41467-023-37420-0. Nat Commun. 2023. PMID: 36964178 Free PMC article.
Functional T cells are capable of supernumerary cell division and longevity.
Soerens AG, Künzli M, Quarnstrom CF, Scott MC, Swanson L, Locquiao JJ, Ghoneim HE, Zehn D, Youngblood B, Vezys V, Masopust D. Soerens AG, et al. Among authors: ghoneim he. Nature. 2023 Feb;614(7949):762-766. doi: 10.1038/s41586-022-05626-9. Epub 2023 Jan 18. Nature. 2023. PMID: 36653453
Epigenetic remodeling by vitamin C potentiates plasma cell differentiation.
Chen HY, Almonte-Loya A, Lay FY, Hsu M, Johnson E, González-Avalos E, Yin J, Bruno RS, Ma Q, Ghoneim HE, Wozniak DJ, Harrison FE, Lio CJ. Chen HY, et al. Among authors: ghoneim he. Elife. 2022 Sep 7;11:e73754. doi: 10.7554/eLife.73754. Elife. 2022. PMID: 36069787 Free PMC article.
Gene Regulatory Circuits in Innate and Adaptive Immune Cells.
Saini A, Ghoneim HE, Lio CJ, Collins PL, Oltz EM. Saini A, et al. Among authors: ghoneim he. Annu Rev Immunol. 2022 Apr 26;40:387-411. doi: 10.1146/annurev-immunol-101320-025949. Epub 2022 Feb 4. Annu Rev Immunol. 2022. PMID: 35119910 Free PMC article. Review.
T cell exhaustion-a memory locked behind scars.
Yousif A, Ghoneim HE. Yousif A, et al. Among authors: ghoneim he. Nat Immunol. 2021 Aug;22(8):938-940. doi: 10.1038/s41590-021-00977-3. Nat Immunol. 2021. PMID: 34312546 No abstract available.
28 results