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Targeted activation of human ether-à-go-go-related gene channels rescues electrical instability induced by the R56Q+/- long QT syndrome variant.
Venkateshappa R, Hunter DV, Muralidharan P, Nagalingam RS, Huen G, Faizi S, Luthra S, Lin E, Cheng YM, Hughes J, Khelifi R, Dhunna DP, Johal R, Sergeev V, Shafaattalab S, Julian LM, Poburko DT, Laksman Z, Tibbits GF, Claydon TW. Venkateshappa R, et al. Among authors: shafaattalab s. Cardiovasc Res. 2023 Nov 25;119(15):2522-2535. doi: 10.1093/cvr/cvad155. Cardiovasc Res. 2023. PMID: 37739930
The hERG channel activator, RPR260243, enhances protective IKr current early in the refractory period reducing arrhythmogenicity in zebrafish hearts.
Shi YP, Pang Z, Venkateshappa R, Gunawan M, Kemp J, Truong E, Chang C, Lin E, Shafaattalab S, Faizi S, Rayani K, Tibbits GF, Claydon VE, Claydon TW. Shi YP, et al. Among authors: shafaattalab s. Am J Physiol Heart Circ Physiol. 2020 Aug 1;319(2):H251-H261. doi: 10.1152/ajpheart.00038.2020. Epub 2020 Jun 19. Am J Physiol Heart Circ Physiol. 2020. PMID: 32559136 Free article.
Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds.
Hull CM, Genge CE, Hobbs Y, Rayani K, Lin E, Gunawan M, Shafaattalab S, Tibbits GF, Claydon TW. Hull CM, et al. Among authors: shafaattalab s. Am J Physiol Regul Integr Comp Physiol. 2019 Dec 1;317(6):R921-R931. doi: 10.1152/ajpregu.00190.2019. Epub 2019 Oct 30. Am J Physiol Regul Integr Comp Physiol. 2019. PMID: 31664867 Free PMC article.
In vitro analyses of suspected arrhythmogenic thin filament variants as a cause of sudden cardiac death in infants.
Shafaattalab S, Li AY, Lin E, Stevens CM, Dewar LJ, Lynn FC, Sanatani S, Laksman Z, Morin RD, van Petegem F, Hove-Madsen L, Tieleman DP, Davis JP, Tibbits GF. Shafaattalab S, et al. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6969-6974. doi: 10.1073/pnas.1819023116. Epub 2019 Mar 18. Proc Natl Acad Sci U S A. 2019. PMID: 30886088 Free PMC article.
21 results