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Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R.
Mathi GR, Kang CH, Lee HK, Achary R, Lee HY, Lee JY, Ha JD, Ahn S, Park CH, Lee CO, Hwang JY, Yun CS, Jung HJ, Cho SY, Kim HR, Kim P. Mathi GR, et al. Among authors: lee co, lee jy, lee hy, lee hk. Eur J Med Chem. 2017 Jan 27;126:536-549. doi: 10.1016/j.ejmech.2016.11.046. Epub 2016 Nov 24. Eur J Med Chem. 2017. PMID: 27915169
Discovery of a New Sulfonamide Hepatitis B Capsid Assembly Modulator.
Na HG, Imran A, Kim K, Han HS, Lee YJ, Kim MJ, Yun CS, Jung YS, Lee JY, Han SB. Na HG, et al. Among authors: lee jy, lee yj. ACS Med Chem Lett. 2020 Jan 9;11(2):166-171. doi: 10.1021/acsmedchemlett.9b00550. eCollection 2020 Feb 13. ACS Med Chem Lett. 2020. PMID: 32071684 Free PMC article.
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