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How myosin VI traps its off-state, is activated and dimerizes.
Canon L, Kikuti C, Planelles-Herrero VJ, Lin T, Mayeux F, Sirkia H, Lee YI, Heidsieck L, Velikovsky L, David A, Liu X, Moussaoui D, Forest E, Höök P, Petersen KJ, Morgan TE, Di Cicco A, Sirés-Campos J, Derivery E, Lévy D, Delevoye C, Sweeney HL, Houdusse A. Canon L, et al. Among authors: planelles herrero vj. Nat Commun. 2023 Oct 23;14(1):6732. doi: 10.1038/s41467-023-42376-2. Nat Commun. 2023. PMID: 37872146 Free PMC article.
Myosin 7 and its adaptors link cadherins to actin.
Yu IM, Planelles-Herrero VJ, Sourigues Y, Moussaoui D, Sirkia H, Kikuti C, Stroebel D, Titus MA, Houdusse A. Yu IM, et al. Nat Commun. 2017 Jun 29;8:15864. doi: 10.1038/ncomms15864. Nat Commun. 2017. PMID: 28660889 Free PMC article.
Myosin MyTH4-FERM structures highlight important principles of convergent evolution.
Planelles-Herrero VJ, Blanc F, Sirigu S, Sirkia H, Clause J, Sourigues Y, Johnsrud DO, Amigues B, Cecchini M, Gilbert SP, Houdusse A, Titus MA. Planelles-Herrero VJ, et al. Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2906-15. doi: 10.1073/pnas.1600736113. Epub 2016 May 10. Proc Natl Acad Sci U S A. 2016. PMID: 27166421 Free PMC article.
Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
Sirigu S, Hartman JJ, Planelles-Herrero VJ, Ropars V, Clancy S, Wang X, Chuang G, Qian X, Lu PP, Barrett E, Rudolph K, Royer C, Morgan BP, Stura EA, Malik FI, Houdusse AM. Sirigu S, et al. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7448-E7455. doi: 10.1073/pnas.1609342113. Epub 2016 Nov 4. Proc Natl Acad Sci U S A. 2016. PMID: 27815532 Free PMC article.
Macromolecular condensation buffers intracellular water potential.
Watson JL, Seinkmane E, Styles CT, Mihut A, Krüger LK, McNally KE, Planelles-Herrero VJ, Dudek M, McCall PM, Barbiero S, Vanden Oever M, Peak-Chew SY, Porebski BT, Zeng A, Rzechorzek NM, Wong DCS, Beale AD, Stangherlin A, Riggi M, Iwasa J, Morf J, Miliotis C, Guna A, Inglis AJ, Brugués J, Voorhees RM, Chambers JE, Meng QJ, O'Neill JS, Edgar RS, Derivery E. Watson JL, et al. Among authors: planelles herrero vj. Nature. 2023 Nov;623(7988):842-852. doi: 10.1038/s41586-023-06626-z. Epub 2023 Oct 18. Nature. 2023. PMID: 37853127 Free PMC article.
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