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How myosin VI traps its off-state, is activated and dimerizes.
Canon L, Kikuti C, Planelles-Herrero VJ, Lin T, Mayeux F, Sirkia H, Lee YI, Heidsieck L, Velikovsky L, David A, Liu X, Moussaoui D, Forest E, Höök P, Petersen KJ, Morgan TE, Di Cicco A, Sirés-Campos J, Derivery E, Lévy D, Delevoye C, Sweeney HL, Houdusse A. Canon L, et al. Among authors: sirkia h. Nat Commun. 2023 Oct 23;14(1):6732. doi: 10.1038/s41467-023-42376-2. Nat Commun. 2023. PMID: 37872146 Free PMC article.
Myosin 7 and its adaptors link cadherins to actin.
Yu IM, Planelles-Herrero VJ, Sourigues Y, Moussaoui D, Sirkia H, Kikuti C, Stroebel D, Titus MA, Houdusse A. Yu IM, et al. Among authors: sirkia h. Nat Commun. 2017 Jun 29;8:15864. doi: 10.1038/ncomms15864. Nat Commun. 2017. PMID: 28660889 Free PMC article.
Optimized filopodia formation requires myosin tail domain cooperation.
Arthur AL, Songster LD, Sirkia H, Bhattacharya A, Kikuti C, Borrega FP, Houdusse A, Titus MA. Arthur AL, et al. Among authors: sirkia h. Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22196-22204. doi: 10.1073/pnas.1901527116. Epub 2019 Oct 14. Proc Natl Acad Sci U S A. 2019. PMID: 31611382 Free PMC article.
Myosin MyTH4-FERM structures highlight important principles of convergent evolution.
Planelles-Herrero VJ, Blanc F, Sirigu S, Sirkia H, Clause J, Sourigues Y, Johnsrud DO, Amigues B, Cecchini M, Gilbert SP, Houdusse A, Titus MA. Planelles-Herrero VJ, et al. Among authors: sirkia h. Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2906-15. doi: 10.1073/pnas.1600736113. Epub 2016 May 10. Proc Natl Acad Sci U S A. 2016. PMID: 27166421 Free PMC article.
Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6.
Ranaivoson FM, Crozet V, Benoit MPMH, Abdalla Mohammed Khalid A, Kikuti C, Sirkia H, El Marjou A, Miserey-Lenkei S, Asenjo AB, Sosa H, Schmidt CF, Rosenfeld SS, Houdusse A. Ranaivoson FM, et al. Among authors: sirkia h. Open Biol. 2023 Sep;13(9):230122. doi: 10.1098/rsob.230122. Epub 2023 Sep 20. Open Biol. 2023. PMID: 37726093 Free PMC article.