Lai L - Search Results

1

Photoaffinity labeling coupled with proteomics identify PDI-ADAM17 module is targeted by (-)-vinigrol to induce TNFR1 shedding and ameliorate rheumatoid arthritis in mice.

Zhu Y, Wang L, Li J, Zhao Y, Yu X, Liu P, Deng X, Liu J, Yang F, Zhang Y, Yu J, Lai L, Wang C, Li Z, Wang L, Luo T. Zhu Y, et al. Among authors: lai l. Cell Chem Biol. 2024 Mar 21;31(3):452-464.e10. doi: 10.1016/j.chembiol.2023.10.003. Epub 2023 Oct 31. Cell Chem Biol. 2024. PMID: 37913771

2

Computation of octanol-water partition coefficients by guiding an additive model with knowledge.

Cheng T, Zhao Y, Li X, Lin F, Xu Y, Zhang X, Li Y, Wang R, Lai L. Cheng T, et al. Among authors: lai l. J Chem Inf Model. 2007 Nov-Dec;47(6):2140-8. doi: 10.1021/ci700257y. Epub 2007 Nov 7. J Chem Inf Model. 2007. PMID: 17985865

3

Flux balance analysis of ammonia assimilation network in E. coli predicts preferred regulation point.

Wang L, Lai L, Ouyang Q, Tang C. Wang L, et al. Among authors: lai l. PLoS One. 2011 Jan 25;6(1):e16362. doi: 10.1371/journal.pone.0016362. PLoS One. 2011. PMID: 21283535 Free PMC article.

4

Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E(2) synthase-1.

Shang E, Wu Y, Liu P, Liu Y, Zhu W, Deng X, He C, He S, Li C, Lai L. Shang E, et al. Among authors: lai l. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2764-7. doi: 10.1016/j.bmcl.2014.04.006. Epub 2014 Apr 13. Bioorg Med Chem Lett. 2014. PMID: 24794107

5

Discovery of highly potent TNFα inhibitors using virtual screen.

Shen Q, Chen J, Wang Q, Deng X, Liu Y, Lai L. Shen Q, et al. Among authors: lai l. Eur J Med Chem. 2014 Oct 6;85:119-26. doi: 10.1016/j.ejmech.2014.07.091. Epub 2014 Jul 25. Eur J Med Chem. 2014. PMID: 25078315

6

Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.

Wang Q, Liberti MV, Liu P, Deng X, Liu Y, Locasale JW, Lai L. Wang Q, et al. Among authors: lai l. Cell Chem Biol. 2017 Jan 19;24(1):55-65. doi: 10.1016/j.chembiol.2016.11.013. Epub 2016 Dec 29. Cell Chem Biol. 2017. PMID: 28042046 Free PMC article.

7

Design, Synthesis, and Evaluation of Dihydrobenzo[cd]indole-6-sulfonamide as TNF-α Inhibitors.

Deng X, Zhang X, Tang B, Liu H, Shen Q, Liu Y, Lai L. Deng X, et al. Among authors: lai l. Front Chem. 2018 Apr 4;6:98. doi: 10.3389/fchem.2018.00098. eCollection 2018. Front Chem. 2018. PMID: 29670876 Free PMC article.

8

A novel allosteric inhibitor that prevents IKKβ activation.

Liu H, Liang H, Meng H, Deng X, Zhang X, Lai L. Liu H, et al. Among authors: lai l. Medchemcomm. 2018 Jan 9;9(2):239-243. doi: 10.1039/c7md00599g. eCollection 2018 Feb 1. Medchemcomm. 2018. PMID: 30108917 Free PMC article.

9

Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy.

Li C, Deng X, Xie X, Liu Y, Friedmann Angeli JP, Lai L. Li C, et al. Among authors: lai l. Front Pharmacol. 2018 Oct 3;9:1120. doi: 10.3389/fphar.2018.01120. eCollection 2018. Front Pharmacol. 2018. PMID: 30337875 Free PMC article.

10

Deep learning for molecular generation.

Xu Y, Lin K, Wang S, Wang L, Cai C, Song C, Lai L, Pei J. Xu Y, et al. Among authors: lai l. Future Med Chem. 2019 Mar;11(6):567-597. doi: 10.4155/fmc-2018-0358. Epub 2019 Jan 30. Future Med Chem. 2019. PMID: 30698019 Review.

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