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Rationale and protocol for a safety, tolerability and feasibility randomized, parallel group, double-blind, placebo-controlled, pilot study of a novel ketone ester targeting frailty via immunometabolic geroscience mechanisms.
medRxiv [Preprint]. 2023 Oct 26:2023.10.25.23297571. doi: 10.1101/2023.10.25.23297571.
medRxiv. 2023.
PMID: 37961234
Free PMC article.
Preprint.
A randomized open-label, observational study of the novel ketone ester, bis octanoyl (R)-1,3-butanediol, and its acute effect on ß-hydroxybutyrate and glucose concentrations in healthy older adults.
Stephens EB, Senadheera C, Roa-Diaz S, Peralta S, Alexander L, Silverman-Martin W, Yukawa M, Morris J, Johnson JB, Newman JC, Stubbs BJ.
Stephens EB, et al. Among authors: silverman martin w.
medRxiv [Preprint]. 2024 Apr 18:2024.04.16.24305925. doi: 10.1101/2024.04.16.24305925.
medRxiv. 2024.
PMID: 38699344
Free PMC article.
Preprint.
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Daily consumption of ketone ester, bis-octanoyl (R)-1,3-butanediol, is safe and tolerable in healthy older adults, a randomized, parallel arm, double-blind, placebo-controlled, pilot study.
Stubbs BJ, Stephens EB, Senadheera C, Peralta S, Roa-Diaz S, Alexander L, Silverman-Martin W, Garcia TY, Yukawa M, Morris J, Blonquist TM, Johnson JB, Newman JC.
Stubbs BJ, et al. Among authors: silverman martin w.
medRxiv [Preprint]. 2024 May 5:2024.05.03.24306699. doi: 10.1101/2024.05.03.24306699.
medRxiv. 2024.
PMID: 38746215
Free PMC article.
Preprint.
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