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The intrinsic substrate specificity of the human tyrosine kinome.
Yaron-Barir TM, Joughin BA, Huntsman EM, Kerelsky A, Cizin DM, Cohen BM, Regev A, Song J, Vasan N, Lin TY, Orozco JM, Schoenherr C, Sagum C, Bedford MT, Wynn RM, Tso SC, Chuang DT, Li L, Li SS, Creixell P, Krismer K, Takegami M, Lee H, Zhang B, Lu J, Cossentino I, Landry SD, Uduman M, Blenis J, Elemento O, Frame MC, Hornbeck PV, Cantley LC, Turk BE, Yaffe MB, Johnson JL. Yaron-Barir TM, et al. Among authors: creixell p. Nature. 2024 May;629(8014):1174-1181. doi: 10.1038/s41586-024-07407-y. Epub 2024 May 8. Nature. 2024. PMID: 38720073
The Fanconi anemia core complex promotes CtIP-dependent end-resection to drive homologous recombination at DNA double-strand breaks.
van de Kooij B, van der Wal FJ, Rother MB, Creixell P, Stout M, Wiegant W, Joughin BA, Vornberger J, van Vugt MATM, Altmeyer M, Yaffe MB, van Attikum H. van de Kooij B, et al. Among authors: creixell p. bioRxiv [Preprint]. 2023 Sep 6:2023.09.05.556391. doi: 10.1101/2023.09.05.556391. bioRxiv. 2023. PMID: 37732274 Free PMC article. Preprint.
Global view of the RAF-MEK-ERK module and its immediate downstream effectors.
Santini CC, Longden J, Schoof EM, Simpson CD, Jeschke GR, Creixell P, Kim J, Wu X, Turk BE, Rosen N, Poulikakos PI, Linding R. Santini CC, et al. Among authors: creixell p. Sci Rep. 2019 Jul 26;9(1):10865. doi: 10.1038/s41598-019-47245-x. Sci Rep. 2019. PMID: 31350469 Free PMC article.
Engineering allosteric regulation in protein kinases.
Pincus D, Pandey JP, Feder ZA, Creixell P, Resnekov O, Reynolds KA. Pincus D, et al. Among authors: creixell p. Sci Signal. 2018 Nov 6;11(555):eaar3250. doi: 10.1126/scisignal.aar3250. Sci Signal. 2018. PMID: 30401787 Free PMC article.
Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution.
Zhao B, Sedlak JC, Srinivas R, Creixell P, Pritchard JR, Tidor B, Lauffenburger DA, Hemann MT. Zhao B, et al. Among authors: creixell p. Cell. 2016 Mar 24;165(1):234-246. doi: 10.1016/j.cell.2016.01.045. Epub 2016 Feb 25. Cell. 2016. PMID: 26924578 Free PMC article.
Unmasking determinants of specificity in the human kinome.
Creixell P, Palmeri A, Miller CJ, Lou HJ, Santini CC, Nielsen M, Turk BE, Linding R. Creixell P, et al. Cell. 2015 Sep 24;163(1):187-201. doi: 10.1016/j.cell.2015.08.057. Epub 2015 Sep 17. Cell. 2015. PMID: 26388442 Free PMC article.
Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.
Creixell P, Schoof EM, Simpson CD, Longden J, Miller CJ, Lou HJ, Perryman L, Cox TR, Zivanovic N, Palmeri A, Wesolowska-Andersen A, Helmer-Citterich M, Ferkinghoff-Borg J, Itamochi H, Bodenmiller B, Erler JT, Turk BE, Linding R. Creixell P, et al. Cell. 2015 Sep 24;163(1):202-17. doi: 10.1016/j.cell.2015.08.056. Epub 2015 Sep 17. Cell. 2015. PMID: 26388441 Free PMC article.
18 results