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Early enterovirus translation deficits extend viral RNA replication and elicit sustained MDA5-directed innate signaling.
mBio. 2023 Nov 14;14(6):e0191523. doi: 10.1128/mbio.01915-23. Online ahead of print.
mBio. 2023.
PMID: 37962360
Free PMC article.
PKR Binds Enterovirus IRESs, Displaces Host Translation Factors, and Impairs Viral Translation to Enable Innate Antiviral Signaling.
Dobrikov MI, Dobrikova EY, McKay ZP, Kastan JP, Brown MC, Gromeier M.
Dobrikov MI, et al. Among authors: mckay zp.
mBio. 2022 Jun 28;13(3):e0085422. doi: 10.1128/mbio.00854-22. Epub 2022 Jun 2.
mBio. 2022.
PMID: 35652592
Free PMC article.
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Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling.
Brown MC, Mosaheb MM, Mohme M, McKay ZP, Holl EK, Kastan JP, Yang Y, Beasley GM, Hwang ES, Ashley DM, Bigner DD, Nair SK, Gromeier M.
Brown MC, et al. Among authors: mckay zp.
Nat Commun. 2021 Mar 25;12(1):1858. doi: 10.1038/s41467-021-22088-1.
Nat Commun. 2021.
PMID: 33767151
Free PMC article.
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Aryl Hydrocarbon Receptor Signaling Controls CD155 Expression on Macrophages and Mediates Tumor Immunosuppression.
McKay ZP, Brown MC, Gromeier M.
McKay ZP, et al.
J Immunol. 2021 Mar 15;206(6):1385-1394. doi: 10.4049/jimmunol.2000792. Epub 2021 Jan 27.
J Immunol. 2021.
PMID: 33504618
Free PMC article.
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Intratumor childhood vaccine-specific CD4+ T-cell recall coordinates antitumor CD8+ T cells and eosinophils.
Brown MC, Beasley GM, McKay ZP, Yang Y, Desjardins A, Randazzo DM, Landi D, Ashley DM, Bigner DD, Nair SK, Gromeier M.
Brown MC, et al. Among authors: mckay zp.
J Immunother Cancer. 2023 Apr;11(4):e006463. doi: 10.1136/jitc-2022-006463.
J Immunother Cancer. 2023.
PMID: 37072349
Free PMC article.
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CD155 is a putative therapeutic target in medulloblastoma.
Li S, McLendon R, Sankey E, Kornahrens R, Lyne AM, Cavalli FMG, McKay Z, Herndon JE 2nd, Remke M, Picard D, Gromeier M, Brown M, Thompson EM.
Li S, et al.
Clin Transl Oncol. 2023 Mar;25(3):696-705. doi: 10.1007/s12094-022-02975-9. Epub 2022 Oct 27.
Clin Transl Oncol. 2023.
PMID: 36301489
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Recombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial.
Thompson EM, Landi D, Brown MC, Friedman HS, McLendon R, Herndon JE 2nd, Buckley E, Bolognesi DP, Lipp E, Schroeder K, Becher OJ, Friedman AH, McKay Z, Walter A, Threatt S, Jaggers D, Desjardins A, Gromeier M, Bigner DD, Ashley DM.
Thompson EM, et al.
Lancet Child Adolesc Health. 2023 Jul;7(7):471-478. doi: 10.1016/S2352-4642(23)00031-7. Epub 2023 Mar 30.
Lancet Child Adolesc Health. 2023.
PMID: 37004712
Clinical Trial.
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