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Cryo-EM of Aβ fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Zielinski M, Peralta Reyes FS, Gremer L, Schemmert S, Frieg B, Schäfer LU, Willuweit A, Donner L, Elvers M, Nilsson LNG, Syvänen S, Sehlin D, Ingelsson M, Willbold D, Schröder GF. Zielinski M, et al. Among authors: willbold d. Nat Neurosci. 2023 Dec;26(12):2073-2080. doi: 10.1038/s41593-023-01484-4. Epub 2023 Nov 16. Nat Neurosci. 2023. PMID: 37973869 Free PMC article.
Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease.
Jiang N, Leithold LH, Post J, Ziehm T, Mauler J, Gremer L, Cremer M, Schartmann E, Shah NJ, Kutzsche J, Langen KJ, Breitkreutz J, Willbold D, Willuweit A. Jiang N, et al. Among authors: willbold d. PLoS One. 2015 Jun 5;10(6):e0128553. doi: 10.1371/journal.pone.0128553. eCollection 2015. PLoS One. 2015. PMID: 26046986 Free PMC article.
QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomers.
Brener O, Dunkelmann T, Gremer L, van Groen T, Mirecka EA, Kadish I, Willuweit A, Kutzsche J, Jürgens D, Rudolph S, Tusche M, Bongen P, Pietruszka J, Oesterhelt F, Langen KJ, Demuth HU, Janssen A, Hoyer W, Funke SA, Nagel-Steger L, Willbold D. Brener O, et al. Among authors: willbold d. Sci Rep. 2015 Sep 23;5:13222. doi: 10.1038/srep13222. Sci Rep. 2015. PMID: 26394756 Free PMC article.
344 results