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HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence.
Cui M, Yamano K, Yamamoto K, Yamamoto-Imoto H, Minami S, Yamamoto T, Matsui S, Kaminishi T, Shima T, Ogura M, Tsuchiya M, Nishino K, Layden BT, Kato H, Ogawa H, Oki S, Okada Y, Isaka Y, Kosako H, Matsuda N, Yoshimori T, Nakamura S. Cui M, et al. Among authors: shima t. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2306454120. doi: 10.1073/pnas.2306454120. Epub 2024 Jan 3. Proc Natl Acad Sci U S A. 2024. PMID: 38170752
Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles.
Kakuda K, Ikenaka K, Kuma A, Doi J, Aguirre C, Wang N, Ajiki T, Choong CJ, Kimura Y, Badawy SMM, Shima T, Nakamura S, Baba K, Nagano S, Nagai Y, Yoshimori T, Mochizuki H. Kakuda K, et al. Among authors: shima t. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2312306120. doi: 10.1073/pnas.2312306120. Epub 2023 Dec 26. Proc Natl Acad Sci U S A. 2024. PMID: 38147546 Free PMC article.
YIPF3 and YIPF4 regulate autophagic turnover of the Golgi apparatus.
Kitta S, Kaminishi T, Higashi M, Shima T, Nishino K, Nakamura N, Kosako H, Yoshimori T, Kuma A. Kitta S, et al. Among authors: shima t. EMBO J. 2024 May 31. doi: 10.1038/s44318-024-00131-3. Online ahead of print. EMBO J. 2024. PMID: 38822137
Differential Effects of Genetic Polymorphism on Comorbid Disease in Metabolic Dysfunction-Associated Steatotic Liver Disease.
Seko Y, Yamaguchi K, Shima T, Iwaki M, Takahashi H, Kawanaka M, Tanaka S, Mitsumoto Y, Yoneda M, Nakajima A, Okanoue T, Itoh Y. Seko Y, et al. Among authors: shima t. Clin Gastroenterol Hepatol. 2024 Apr 10:S1542-3565(24)00311-2. doi: 10.1016/j.cgh.2024.02.031. Online ahead of print. Clin Gastroenterol Hepatol. 2024. PMID: 38604296
844 results