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Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation.
Dijkstra DJ, van de Bovenkamp FS, Abendstein L, Zuijderduijn R, Pool J, Kramer CSM, Slot LM, Drijfhout JW, de Vor L, Gelderman KA, Rooijakkers SHM, Zaldumbide A, Vidarsson G, Sharp TH, Parren PWHI, Trouw LA. Dijkstra DJ, et al. Among authors: sharp th. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2310666120. doi: 10.1073/pnas.2310666120. Epub 2023 Dec 4. Proc Natl Acad Sci U S A. 2023. PMID: 38048459 Free PMC article.
Carbamylation reduces the capacity of IgG for hexamerization and complement activation.
Lubbers R, Oostindie SC, Dijkstra DJ, Parren PWHI, Verheul MK, Abendstein L, Sharp TH, de Ru A, Janssen GMC, van Veelen PA, van den Bremer ETJ, Bleijlevens B, de Kreuk BJ, Beurskens FJ, Trouw LA. Lubbers R, et al. Among authors: sharp th. Clin Exp Immunol. 2020 Apr;200(1):1-11. doi: 10.1111/cei.13411. Epub 2020 Jan 5. Clin Exp Immunol. 2020. PMID: 31853959 Free PMC article.
PTX3 structure determination using a hybrid cryoelectron microscopy and AlphaFold approach offers insights into ligand binding and complement activation.
Noone DP, Dijkstra DJ, van der Klugt TT, van Veelen PA, de Ru AH, Hensbergen PJ, Trouw LA, Sharp TH. Noone DP, et al. Among authors: sharp th. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2208144119. doi: 10.1073/pnas.2208144119. Epub 2022 Aug 8. Proc Natl Acad Sci U S A. 2022. PMID: 35939690 Free PMC article.
46 results