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Page 1
Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation.
Dijkstra DJ, van de Bovenkamp FS, Abendstein L, Zuijderduijn R, Pool J, Kramer CSM, Slot LM, Drijfhout JW, de Vor L, Gelderman KA, Rooijakkers SHM, Zaldumbide A, Vidarsson G, Sharp TH, Parren PWHI, Trouw LA. Dijkstra DJ, et al. Among authors: slot lm. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2310666120. doi: 10.1073/pnas.2310666120. Epub 2023 Dec 4. Proc Natl Acad Sci U S A. 2023. PMID: 38048459 Free PMC article.
Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load.
Reijm S, Kissel T, Stoeken-Rijsbergen G, Slot LM, Wortel CM, van Dooren HJ, Levarht NEW, Kampstra ASB, Derksen VFAM, Heer PO, Bang H, Drijfhout JW, Trouw LA, Huizinga TWJ, Rispens T, Scherer HU, Toes REM. Reijm S, et al. Among authors: slot lm. Arthritis Res Ther. 2021 Sep 3;23(1):230. doi: 10.1186/s13075-021-02609-5. Arthritis Res Ther. 2021. PMID: 34479638 Free PMC article.
Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications.
Kissel T, Reijm S, Slot LM, Cavallari M, Wortel CM, Vergroesen RD, Stoeken-Rijsbergen G, Kwekkeboom JC, Kampstra A, Levarht E, Drijfhout JW, Bang H, Bonger KM, Janssen G, van Veelen PA, Huizinga T, Scherer HU, Reth M, Toes R. Kissel T, et al. Among authors: slot lm. Ann Rheum Dis. 2020 Apr;79(4):472-480. doi: 10.1136/annrheumdis-2019-216499. Epub 2020 Feb 10. Ann Rheum Dis. 2020. PMID: 32041746
Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation.
Kissel T, Ge C, Hafkenscheid L, Kwekkeboom JC, Slot LM, Cavallari M, He Y, van Schie KA, Vergroesen RD, Kampstra ASB, Reijm S, Stoeken-Rijsbergen G, Koeleman C, Voortman LM, Heitman LH, Xu B, Pruijn GJM, Wuhrer M, Rispens T, Huizinga TWJ, Scherer HU, Reth M, Holmdahl R, Toes REM. Kissel T, et al. Among authors: slot lm. Sci Adv. 2022 Feb 11;8(6):eabm1759. doi: 10.1126/sciadv.abm1759. Epub 2022 Feb 9. Sci Adv. 2022. PMID: 35138894 Free PMC article.
Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis.
Kristyanto H, Blomberg NJ, Slot LM, van der Voort EIH, Kerkman PF, Bakker A, Burgers LE, Ten Brinck RM, van der Helm-van Mil AHM, Spits H, Baeten DL, Huizinga TWJ, Toes REM, Scherer HU. Kristyanto H, et al. Among authors: slot lm. Sci Transl Med. 2020 Nov 18;12(570):eaaz5327. doi: 10.1126/scitranslmed.aaz5327. Sci Transl Med. 2020. PMID: 33208502 Free PMC article.
A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis.
He Y, Ge C, Moreno-Giró À, Xu B, Beusch CM, Sandor K, Su J, Cheng L, Lönnblom E, Lundqvist C, Slot LM, Tong D, Urbonaviciute V, Liang B, Li T, Lahore GF, Aoun M, Malmström V, Rispens T, Ernfors P, Svensson CI, Scherer HU, Toes REM, Gjertsson I, Ekwall O, Zubarev RA, Holmdahl R. He Y, et al. Among authors: slot lm. Nat Commun. 2023 Feb 8;14(1):691. doi: 10.1038/s41467-023-36257-x. Nat Commun. 2023. PMID: 36754962 Free PMC article.
MuSK myasthenia gravis monoclonal antibodies: Valency dictates pathogenicity.
Huijbers MG, Vergoossen DL, Fillié-Grijpma YE, van Es IE, Koning MT, Slot LM, Veelken H, Plomp JJ, van der Maarel SM, Verschuuren JJ. Huijbers MG, et al. Among authors: slot lm. Neurol Neuroimmunol Neuroinflamm. 2019 Feb 21;6(3):e547. doi: 10.1212/NXI.0000000000000547. eCollection 2019 May. Neurol Neuroimmunol Neuroinflamm. 2019. PMID: 30882021 Free PMC article.
17 results