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The autoinflammation-associated NLRC4V341A mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice.
Eeckhout E, Asaoka T, Van Gorp H, Demon D, Girard-Guyonvarc'h C, Andries V, Vereecke L, Gabay C, Lamkanfi M, van Loo G, Wullaert A. Eeckhout E, et al. Among authors: demon d. Front Immunol. 2023 Nov 28;14:1272639. doi: 10.3389/fimmu.2023.1272639. eCollection 2023. Front Immunol. 2023. PMID: 38090573 Free PMC article.
GSDMD drives canonical inflammasome-induced neutrophil pyroptosis and is dispensable for NETosis.
Chauhan D, Demon D, Vande Walle L, Paerewijck O, Zecchin A, Bosseler L, Santoni K, Planès R, Ribo S, Fossoul A, Gonçalves A, Van Gorp H, Van Opdenbosch N, Van Hauwermeiren F, Meunier E, Wullaert A, Lamkanfi M. Chauhan D, et al. Among authors: demon d. EMBO Rep. 2022 Oct 6;23(10):e54277. doi: 10.15252/embr.202154277. Epub 2022 Jul 28. EMBO Rep. 2022. PMID: 35899491 Free PMC article.
Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.
Walle LV, Stowe IB, Šácha P, Lee BL, Demon D, Fossoul A, Van Hauwermeiren F, Saavedra PHV, Šimon P, Šubr V, Kostka L, Stivala CE, Pham VC, Staben ST, Yamazoe S, Konvalinka J, Kayagaki N, Lamkanfi M. Walle LV, et al. Among authors: demon d. PLoS Biol. 2019 Oct 16;17(10):e3000529. doi: 10.1371/journal.pbio.3000529. eCollection 2019 Oct. PLoS Biol. 2019. PMID: 31618263 Free PMC article.
MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.
Vande Walle L, Stowe IB, Šácha P, Lee BL, Demon D, Fossoul A, Van Hauwermeiren F, Saavedra PHV, Šimon P, Šubrt V, Kostka L, Stivala CE, Pham VC, Staben ST, Yamazoe S, Konvalinka J, Kayagaki N, Lamkanfi M. Vande Walle L, et al. Among authors: demon d. PLoS Biol. 2019 Sep 16;17(9):e3000354. doi: 10.1371/journal.pbio.3000354. eCollection 2019 Sep. PLoS Biol. 2019. PMID: 31525186 Free PMC article.
Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4.
Van Opdenbosch N, Van Gorp H, Verdonckt M, Saavedra PHV, de Vasconcelos NM, Gonçalves A, Vande Walle L, Demon D, Matusiak M, Van Hauwermeiren F, D'Hont J, Hochepied T, Krautwald S, Kanneganti TD, Lamkanfi M. Van Opdenbosch N, et al. Among authors: demon d. Cell Rep. 2017 Dec 19;21(12):3427-3444. doi: 10.1016/j.celrep.2017.11.088. Cell Rep. 2017. PMID: 29262324 Free PMC article.
Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections.
Hassane M, Demon D, Soulard D, Fontaine J, Keller LE, Patin EC, Porte R, Prinz I, Ryffel B, Kadioglu A, Veening JW, Sirard JC, Faveeuw C, Lamkanfi M, Trottein F, Paget C. Hassane M, et al. Among authors: demon d. Mucosal Immunol. 2017 Jul;10(4):1056-1068. doi: 10.1038/mi.2016.113. Epub 2017 Jan 4. Mucosal Immunol. 2017. PMID: 28051086 Free article.
Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation.
Van Gorp H, Saavedra PH, de Vasconcelos NM, Van Opdenbosch N, Vande Walle L, Matusiak M, Prencipe G, Insalaco A, Van Hauwermeiren F, Demon D, Bogaert DJ, Dullaers M, De Baere E, Hochepied T, Dehoorne J, Vermaelen KY, Haerynck F, De Benedetti F, Lamkanfi M. Van Gorp H, et al. Among authors: demon d. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14384-14389. doi: 10.1073/pnas.1613156113. Epub 2016 Nov 22. Proc Natl Acad Sci U S A. 2016. PMID: 27911804 Free PMC article.
Does caspase-12 suppress inflammasome activation?
Vande Walle L, Jiménez Fernández D, Demon D, Van Laethem N, Van Hauwermeiren F, Van Gorp H, Van Opdenbosch N, Kayagaki N, Lamkanfi M. Vande Walle L, et al. Among authors: demon d. Nature. 2016 Jun 2;534(7605):E1-4. doi: 10.1038/nature17649. Nature. 2016. PMID: 27251234 No abstract available.
Complementarity and redundancy of IL-22-producing innate lymphoid cells.
Rankin LC, Girard-Madoux MJ, Seillet C, Mielke LA, Kerdiles Y, Fenis A, Wieduwild E, Putoczki T, Mondot S, Lantz O, Demon D, Papenfuss AT, Smyth GK, Lamkanfi M, Carotta S, Renauld JC, Shi W, Carpentier S, Soos T, Arendt C, Ugolini S, Huntington ND, Belz GT, Vivier E. Rankin LC, et al. Among authors: demon d. Nat Immunol. 2016 Feb;17(2):179-86. doi: 10.1038/ni.3332. Epub 2015 Nov 30. Nat Immunol. 2016. PMID: 26595889 Free PMC article.
29 results