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Mitochondrial H2O2 release does not directly cause damage to chromosomal DNA.
van Soest DMK, Polderman PE, den Toom WTF, Keijer JP, van Roosmalen MJ, Leyten TMF, Lehmann J, Zwakenberg S, De Henau S, van Boxtel R, Burgering BMT, Dansen TB. van Soest DMK, et al. Among authors: van roosmalen mj. Nat Commun. 2024 Mar 28;15(1):2725. doi: 10.1038/s41467-024-47008-x. Nat Commun. 2024. PMID: 38548751 Free PMC article.
Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer.
Rosendahl Huber A, Pleguezuelos-Manzano C, Puschhof J, Ubels J, Boot C, Saftien A, Verheul M, Trabut LT, Groenen N, van Roosmalen M, Ouyang KS, Wood H, Quirke P, Meijer G, Cuppen E, Clevers H, van Boxtel R. Rosendahl Huber A, et al. Among authors: van roosmalen m. Cancer Cell. 2024 Mar 11;42(3):487-496.e6. doi: 10.1016/j.ccell.2024.02.009. Cancer Cell. 2024. PMID: 38471458 Free article.
A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation.
Fok ET, Moorlag SJCFM, Negishi Y, Groh LA, Dos Santos JC, Gräwe C, Monge VV, Craenmehr DDD, van Roosmalen M, da Cunha Jolvino DP, Migliorini LB, Neto AS, Severino P, Vermeulen M, Joosten LAB, Netea MG, Fanucchi S, Mhlanga MM. Fok ET, et al. Among authors: van roosmalen m. Nat Genet. 2024 Jan;56(1):85-99. doi: 10.1038/s41588-023-01598-2. Epub 2023 Dec 13. Nat Genet. 2024. PMID: 38092881
Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox.
Middelkamp S, Manders F, Peci F, van Roosmalen MJ, González DM, Bertrums EJM, van der Werf I, Derks LLM, Groenen NM, Verheul M, Trabut L, Pleguezuelos-Manzano C, Brandsma AM, Antoniou E, Reinhardt D, Bierings M, Belderbos ME, van Boxtel R. Middelkamp S, et al. Among authors: van roosmalen mj. Cell Genom. 2023 Aug 23;3(9):100389. doi: 10.1016/j.xgen.2023.100389. eCollection 2023 Sep 13. Cell Genom. 2023. PMID: 37719152 Free PMC article.
A multi-platform reference for somatic structural variation detection.
Espejo Valle-Inclan J, Besselink NJM, de Bruijn E, Cameron DL, Ebler J, Kutzera J, van Lieshout S, Marschall T, Nelen M, Priestley P, Renkens I, Roemer MGM, van Roosmalen MJ, Wenger AM, Ylstra B, Fijneman RJA, Kloosterman WP, Cuppen E. Espejo Valle-Inclan J, et al. Among authors: van roosmalen mj. Cell Genom. 2022 Jun 8;2(6):100139. doi: 10.1016/j.xgen.2022.100139. eCollection 2022 Jun 8. Cell Genom. 2022. PMID: 36778136 Free PMC article.
Elevated Mutational Age in Blood of Children Treated for Cancer Contributes to Therapy-Related Myeloid Neoplasms.
Bertrums EJM, Rosendahl Huber AKM, de Kanter JK, Brandsma AM, van Leeuwen AJCN, Verheul M, van den Heuvel-Eibrink MM, Oka R, van Roosmalen MJ, de Groot-Kruseman HA, Zwaan CM, Goemans BF, van Boxtel R. Bertrums EJM, et al. Among authors: van roosmalen mj. Cancer Discov. 2022 Aug 5;12(8):1860-1872. doi: 10.1158/2159-8290.CD-22-0120. Cancer Discov. 2022. PMID: 35678530 Free PMC article.
MutationalPatterns: the one stop shop for the analysis of mutational processes.
Manders F, Brandsma AM, de Kanter J, Verheul M, Oka R, van Roosmalen MJ, van der Roest B, van Hoeck A, Cuppen E, van Boxtel R. Manders F, et al. Among authors: van roosmalen mj. BMC Genomics. 2022 Feb 15;23(1):134. doi: 10.1186/s12864-022-08357-3. BMC Genomics. 2022. PMID: 35168570 Free PMC article.
95 results