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Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria.
Moxon CA, Alhamdi Y, Storm J, Toh JMH, McGuinness D, Ko JY, Murphy G, Lane S, Taylor TE, Seydel KB, Kampondeni S, Potchen M, O'Donnell JS, O'Regan N, Wang G, García-Cardeña G, Molyneux M, Craig AG, Abrams ST, Toh CH. Moxon CA, et al. Blood Adv. 2020 Jul 14;4(13):2851-2864. doi: 10.1182/bloodadvances.2019001258. Blood Adv. 2020. PMID: 32579667 Free PMC article.
Parasite histones mediate blood-brain barrier disruption in cerebral malaria.
Moxon C, Alhamdi Y, Storm J, Toh J, Ko JY, Murphy G, Taylor T, Seydel K, Wang G, García-Car G, Molyneux M, Craig A, Abrams S, Toh CH. Moxon C, et al. Clin Med (Lond). 2020 Mar;20(Suppl 2):s96-s97. doi: 10.7861/clinmed.20-2-s96. Clin Med (Lond). 2020. PMID: 32409404 Free PMC article. No abstract available.
New Insights into Malaria Pathogenesis.
Moxon CA, Gibbins MP, McGuinness D, Milner DA Jr, Marti M. Moxon CA, et al. Annu Rev Pathol. 2020 Jan 24;15:315-343. doi: 10.1146/annurev-pathmechdis-012419-032640. Epub 2019 Oct 24. Annu Rev Pathol. 2020. PMID: 31648610 Review.
Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding.
Moxon CA, Chisala NV, Mzikamanda R, MacCormick I, Harding S, Downey C, Molyneux M, Seydel KB, Taylor TE, Heyderman RS, Toh CH. Moxon CA, et al. J Thromb Haemost. 2015 Sep;13(9):1653-64. doi: 10.1111/jth.13060. Epub 2015 Aug 27. J Thromb Haemost. 2015. PMID: 26186686 Free PMC article.
Neutrophil extracellular traps drive inflammatory pathogenesis in malaria.
Knackstedt SL, Georgiadou A, Apel F, Abu-Abed U, Moxon CA, Cunnington AJ, Raupach B, Cunningham D, Langhorne J, Krüger R, Barrera V, Harding SP, Berg A, Patel S, Otterdal K, Mordmüller B, Schwarzer E, Brinkmann V, Zychlinsky A, Amulic B. Knackstedt SL, et al. Sci Immunol. 2019 Oct 18;4(40):eaaw0336. doi: 10.1126/sciimmunol.aaw0336. Sci Immunol. 2019. PMID: 31628160 Free PMC article.
34 results