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Molecular basis of proton-sensing by G protein-coupled receptors.
Howard MK, Hoppe N, Huang XP, Macdonald CB, Mehrota E, Grimes PR, Zahm A, Trinidad DD, English J, Coyote-Maestas W, Manglik A. Howard MK, et al. Among authors: manglik a. bioRxiv [Preprint]. 2024 Apr 18:2024.04.17.590000. doi: 10.1101/2024.04.17.590000. bioRxiv. 2024. PMID: 38659943 Free PMC article. Preprint.
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter JF, Dror RO, Evers AS, Mukhopadhyay S, Manglik A. Hoppe N, et al. Among authors: manglik a. Nat Struct Mol Biol. 2024 Apr;31(4):667-677. doi: 10.1038/s41594-024-01223-8. Epub 2024 Feb 7. Nat Struct Mol Biol. 2024. PMID: 38326651
Structural Basis of μ-Opioid Receptor-Targeting by a Nanobody Antagonist.
Yu J, Kumar A, Zhang X, Martin C, Raia P, Koehl A, Laeremans T, Steyaert J, Manglik A, Ballet S, Boland A, Stoeber M. Yu J, et al. Among authors: manglik a. bioRxiv [Preprint]. 2023 Dec 7:2023.12.06.570395. doi: 10.1101/2023.12.06.570395. bioRxiv. 2023. PMID: 38106026 Free PMC article. Preprint.
Engineered odorant receptors illuminate structural principles of odor discrimination.
de March CA, Ma N, Billesbølle CB, Tewari J, Del Torrent CL, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H. de March CA, et al. Among authors: manglik a. bioRxiv [Preprint]. 2023 Nov 17:2023.11.16.567230. doi: 10.1101/2023.11.16.567230. bioRxiv. 2023. PMID: 38014344 Free PMC article. Preprint.
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter J, Dror RO, Evers AS, Mukhopadhyay S, Manglik A. Hoppe N, et al. Among authors: manglik a. bioRxiv [Preprint]. 2023 May 24:2023.05.23.540554. doi: 10.1101/2023.05.23.540554. bioRxiv. 2023. PMID: 37292845 Free PMC article. Updated. Preprint.
Structure-based discovery of conformationally selective inhibitors of the serotonin transporter.
Singh I, Seth A, Billesbølle CB, Braz J, Rodriguiz RM, Roy K, Bekele B, Craik V, Huang XP, Boytsov D, Pogorelov VM, Lak P, O'Donnell H, Sandtner W, Irwin JJ, Roth BL, Basbaum AI, Wetsel WC, Manglik A, Shoichet BK, Rudnick G. Singh I, et al. Among authors: manglik a. Cell. 2023 May 11;186(10):2160-2175.e17. doi: 10.1016/j.cell.2023.04.010. Epub 2023 May 2. Cell. 2023. PMID: 37137306 Free PMC article.
Structural basis of odorant recognition by a human odorant receptor.
Billesbølle CB, de March CA, van der Velden WJC, Ma N, Tewari J, Del Torrent CL, Li L, Faust B, Vaidehi N, Matsunami H, Manglik A. Billesbølle CB, et al. Among authors: manglik a. Nature. 2023 Mar;615(7953):742-749. doi: 10.1038/s41586-023-05798-y. Epub 2023 Mar 15. Nature. 2023. PMID: 36922591 Free PMC article.
76 results