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Page 1
Type 2 diabetes mellitus and cardiovascular health: Evidence of causal relationships in a European ancestry population.
Ruan W, Zhou X, Li J, Liu H, Wang T, Zhang G, Lin K. Ruan W, et al. ESC Heart Fail. 2024 Jun 12. doi: 10.1002/ehf2.14877. Online ahead of print. ESC Heart Fail. 2024. PMID: 38867366
MR analysis revealed causal associations between genetic predisposition to T2DM and increased risk of CAD (odds ratio [OR] 1.104, 95% confidence interval [CI] 1.078-1.130, P = 2.59e-16), MI (OR 1.129, 95% CI 1.094-1.166, P = 6.02e-14) and stroke (OR 1.086, 95% CI 1.064-1.109, P = …
MR analysis revealed causal associations between genetic predisposition to T2DM and increased risk of CAD (odds ratio [OR] 1.104, 95% confid …
Genetic drivers and cellular selection of female mosaic X chromosome loss.
Liu A, Genovese G, Zhao Y, Pirinen M, Zekavat SM, Kentistou KA, Yang Z, Yu K, Vlasschaert C, Liu X, Brown DW, Hudjashov G, Gorman BR, Dennis J, Zhou W, Momozawa Y, Pyarajan S, Tuzov V, Pajuste FD, Aavikko M, Sipilä TP, Ghazal A, Huang WY, Freedman ND, Song L, Gardner EJ; FinnGen; Estonian Biobank Research Team; Breast Cancer Association Consortium; Million Veteran Program; Sankaran VG, Palotie A, Ollila HM, Tukiainen T, Chanock SJ, Mägi R, Natarajan P, Daly MJ, Bick A, McCarroll SA, Terao C, Loh PR, Ganna A, Perry JRB, Machiela MJ. Liu A, et al. Nature. 2024 Jun 12. doi: 10.1038/s41586-024-07533-7. Online ahead of print. Nature. 2024. PMID: 38867047
A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk.
Jermy B, Läll K, Wolford BN, Wang Y, Zguro K, Cheng Y, Kanai M, Kanoni S, Yang Z, Hartonen T, Monti R, Wanner J, Youssef O; Estonian Biobank research team; FinnGen; Lippert C, van Heel D, Okada Y, McCartney DL, Hayward C, Marioni RE, Furini S, Renieri A, Martin AR, Neale BM, Hveem K, Mägi R, Palotie A, Heyne H, Mars N, Ganna A, Ripatti S. Jermy B, et al. Nat Commun. 2024 Jun 12;15(1):5007. doi: 10.1038/s41467-024-48938-2. Nat Commun. 2024. PMID: 38866767
TWINGEN: protocol for an observational clinical biobank recall and biomarker cohort study to identify Finnish individuals with high risk of Alzheimer's disease.
Vuoksimaa E, Saari TT, Aaltonen A, Aaltonen S, Herukka SK, Iso-Markku P, Kokkola T, Kyttälä A, Kärkkäinen S, Liedes H, Ollikainen M, Palviainen T, Ruotsalainen I, Toivola A, Urjansson M, Vasankari T, Vähä-Ypyä H, Forsberg MM, Hiltunen M, Jalanko A, Kälviäinen R, Kuopio T, Lähteenmäki J, Nyberg P, Männikkö M, Serpi R, Siltanen S, Palotie A, Kaprio J, Runz H, Julkunen V; FinnGen. Vuoksimaa E, et al. BMJ Open. 2024 Jun 12;14(6):e081947. doi: 10.1136/bmjopen-2023-081947. BMJ Open. 2024. PMID: 38866570 Free article.
The data collected in TWINGEN will be returned to THL Biobank from where it can later be requested for other biobank studies such as FinnGen that supported TWINGEN. ETHICS AND DISSEMINATION: This recall study consists of FTC/THL Biobank/FinnGen participants whose da …
The data collected in TWINGEN will be returned to THL Biobank from where it can later be requested for other biobank studies such as Finn …
Exploring risk factors for autoimmune diseases complicated by non-hodgkin lymphoma through regulatory T cell immune-related traits: a Mendelian randomization study.
Liu Q, Zhou X, Liu K, Wang Y, Liu C, Gao C, Cai Q, Sun C. Liu Q, et al. Front Immunol. 2024 May 28;15:1374938. doi: 10.3389/fimmu.2024.1374938. eCollection 2024. Front Immunol. 2024. PMID: 38863695 Free PMC article.
METHODS: Aggregate data for 84 Treg-related immune traits were downloaded from the Genome-Wide Association Study (GWAS) catalog, and GWAS data for diffuse large B-cell lymphoma (DLBCL; n=315243), follicular lymphoma (FL; n=325831), sjogren's syndrome (SS; n=402090), rheumatoid ar …
METHODS: Aggregate data for 84 Treg-related immune traits were downloaded from the Genome-Wide Association Study (GWAS) catalog, and GWAS da …
Genetic Causal Associations between Various Serum Minerals and Risk of Depression: A Mendelian Randomization Study.
Wang Y, Liu L, Yang D. Wang Y, et al. Actas Esp Psiquiatr. 2024 Jun;52(3):211-220. doi: 10.62641/aep.v52i3.1637. Actas Esp Psiquiatr. 2024. PMID: 38863045
Leveraging summary-level data on depression, a genome-wide association study (GWAS) was applied. The data on serum minerals were collected from the FinnGen Biobank database. MR assessments representing causality were produced by inverse-variance weighted approaches with mu …
Leveraging summary-level data on depression, a genome-wide association study (GWAS) was applied. The data on serum minerals were collected f …
Causal association between circulating blood cell traits and pulmonary embolism: a mendelian randomization study.
Jiang C, Lin J, Xie B, Peng M, Dai Z, Mai S, Chen Q. Jiang C, et al. Thromb J. 2024 Jun 11;22(1):49. doi: 10.1186/s12959-024-00618-3. Thromb J. 2024. PMID: 38863024 Free PMC article.
The lymphocyte subpopulation counts were extracted from summary GWAS statistics for samples from 3757 individuals that had been analyzed by flow cytometry. GWAS data related to PE were obtained from the FinnGen study. RESULTS: According to the SVMR and reverse MR, increase …
The lymphocyte subpopulation counts were extracted from summary GWAS statistics for samples from 3757 individuals that had been analyzed by …
Investigating causal associations between pneumonia and lung cancer using a bidirectional mendelian randomization framework.
Song L, Wu D, Wu J, Zhang J, Li W, Wang C. Song L, et al. BMC Cancer. 2024 Jun 11;24(1):721. doi: 10.1186/s12885-024-12147-3. BMC Cancer. 2024. PMID: 38862880 Free PMC article.
METHODS: Genome-wide association study (GWAS) summary-level data were obtained from the hitherto latest FinnGen database, COVID-19 Host Genetics Initiative resource, and International Lung Cancer Consortium. ...
METHODS: Genome-wide association study (GWAS) summary-level data were obtained from the hitherto latest FinnGen database, COVID-19 Ho …
Whole-genome sequencing identifies variants in ANK1, LRRN1, HAS1, and other genes and regulatory regions for stroke in type 1 diabetes.
Antikainen AA, Haukka JK, Kumar A, Syreeni A, Hägg-Holmberg S, Ylinen A, Kilpeläinen E, Kytölä A, Palotie A, Putaala J, Thorn LM, Harjutsalo V, Groop PH, Sandholm N; FinnDiane Study Group. Antikainen AA, et al. Sci Rep. 2024 Jun 11;14(1):13453. doi: 10.1038/s41598-024-61840-7. Sci Rep. 2024. PMID: 38862513 Free PMC article.
In addition, we attempted replication in T1D using a genome-wide association study (N = 3,945) and direct genotyping (N = 3,263), and in the general population from the large-scale population-wide FinnGen project and UK Biobank summary statistics. We identified a rare miss …
In addition, we attempted replication in T1D using a genome-wide association study (N = 3,945) and direct genotyping (N = 3,263), and in the …
The causality between gut microbiota and non-Hodgkin lymphoma: a two-sample bidirectional Mendelian randomization study.
Fu J, Hao Z. Fu J, et al. Front Microbiol. 2024 May 27;15:1403825. doi: 10.3389/fmicb.2024.1403825. eCollection 2024. Front Microbiol. 2024. PMID: 38860220 Free PMC article.
METHODS: Data on GM is sourced from the MiBioGen consortium, while data on NHL and its subtypes is sourced from the FinnGen consortium R10 version. Inverse variance weighted (IVW) was employed for the primary MR analysis method, with methods such as Bayesian weighted Mende …
METHODS: Data on GM is sourced from the MiBioGen consortium, while data on NHL and its subtypes is sourced from the FinnGen consortiu …
1,133 results