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A randomized double-blind placebo-controlled trial of an inhibitor of plasminogen activator inhibitor-1 (TM5614) in mild to moderate COVID-19.
Hirai T, Asano K, Ito I, Miyazaki Y, Sugiura H, Agirbasli M, Kobayashi S, Kobayashi M, Shimada D, Natsume I, Kawasaki T, Ohba T, Tajiri S, Sakamaki F, Mineshita M, Takihara T, Sekiya K, Tomii K, Tomioka H, Kita H, Nishizaka Y, Fukui M, Miyata T, Harigae H. Hirai T, et al. Among authors: miyata t. Sci Rep. 2024 Jan 2;14(1):165. doi: 10.1038/s41598-023-50445-1. Sci Rep. 2024. PMID: 38168544 Free PMC article. Clinical Trial.
Efficacy and safety of TM5614 in combination with paclitaxel in the treatment of paclitaxel-resistant cutaneous angiosarcoma: Phase II study protocol.
Fujimura T, Yoshino K, Nakamura M, Kato H, Ito T, Maekawa T, Fujisawa Y, Matsushita S, Amagai R, Yamazaki E, Takahashi M, Tamabuchi E, Hashimoto A, Kambayashi Y, Yamazaki N, Miyata T, Asano Y. Fujimura T, et al. Among authors: miyata t. Exp Dermatol. 2024 Jan;33(1):e14976. doi: 10.1111/exd.14976. Epub 2023 Nov 9. Exp Dermatol. 2024. PMID: 37946551
Phase II, multicenter study of plasminogen activator inhibitor-1 inhibitor (TM5614) plus nivolumab for treating anti-PD-1 antibody-refractory malignant melanoma: TM5614-MM trial.
Fujimura T, Yoshino K, Kato H, Fukushima S, Ishizuki S, Otsuka A, Matsushita S, Amagai R, Muto Y, Yamazaki E, Kambayashi Y, Yahata T, Miyata T, Fujisawa Y, Asano Y. Fujimura T, et al. Among authors: miyata t. Br J Dermatol. 2024 Jun 4:ljae231. doi: 10.1093/bjd/ljae231. Online ahead of print. Br J Dermatol. 2024. PMID: 38833158
Treatment rationale and protocol design: an investigator-initiated phase II study of combination treatment of nivolumab and TM5614, a PAI-1 inhibitor for previously treated patients with non-small cell lung cancer.
Masuda T, Hirata T, Sakamoto T, Tsubata Y, Ichihara E, Kozuki T, Shoda H, Motonaga M, Yoshida T, Fukutani M, Tsuji-Takayama K, Tamura A, Amagase H, Fujihara H, Aoki G, Akita T, Orihashi Y, Miyata T, Hattori N. Masuda T, et al. Among authors: miyata t. J Thorac Dis. 2024 May 31;16(5):3381-3388. doi: 10.21037/jtd-23-1858. Epub 2024 May 27. J Thorac Dis. 2024. PMID: 38883673 Free PMC article.
2,202 results