Flynn BL - Search Results

1

BNC210, a negative allosteric modulator of the alpha 7 nicotinic acetylcholine receptor, demonstrates anxiolytic- and antidepressant-like effects in rodents.

O'Connor SM, Sleebs BE, Street IP, Flynn BL, Baell JB, Coles C, Quazi N, Paul D, Poiraud E, Huyard B, Wagner S, Andriambeloson E, de Souza EB. O'Connor SM, et al. Among authors: flynn bl. Neuropharmacology. 2024 Mar 15;246:109836. doi: 10.1016/j.neuropharm.2024.109836. Epub 2024 Jan 6. Neuropharmacology. 2024. PMID: 38185416 Free article.

2

Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3.

Cianci J, Baell JB, Flynn BL, Gable RW, Mould JA, Paul D, Harvey AJ. Cianci J, et al. Among authors: flynn bl. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2055-61. doi: 10.1016/j.bmcl.2008.01.099. Epub 2008 Jan 31. Bioorg Med Chem Lett. 2008. PMID: 18289849

3

Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

Flynn BL, Gill GS, Grobelny DW, Chaplin JH, Paul D, Leske AF, Lavranos TC, Chalmers DK, Charman SA, Kostewicz E, Shackleford DM, Morizzi J, Hamel E, Jung MK, Kremmidiotis G. Flynn BL, et al. J Med Chem. 2011 Sep 8;54(17):6014-27. doi: 10.1021/jm200454y. Epub 2011 Aug 5. J Med Chem. 2011. PMID: 21774499 Free PMC article.

4

2-aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists.

Ferguson GN, Valant C, Horne J, Figler H, Flynn BL, Linden J, Chalmers DK, Sexton PM, Christopoulos A, Scammells PJ. Ferguson GN, et al. Among authors: flynn bl. J Med Chem. 2008 Oct 9;51(19):6165-72. doi: 10.1021/jm800557d. Epub 2008 Sep 5. J Med Chem. 2008. PMID: 18771255 Free PMC article.

5

3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists.

Aurelio L, Valant C, Figler H, Flynn BL, Linden J, Sexton PM, Christopoulos A, Scammells PJ. Aurelio L, et al. Among authors: flynn bl. Bioorg Med Chem. 2009 Oct 15;17(20):7353-61. doi: 10.1016/j.bmc.2009.08.024. Epub 2009 Aug 20. Bioorg Med Chem. 2009. PMID: 19751980 Free PMC article.

6

The effect of dihydroceramide desaturase 1 inhibition on endothelial impairment induced by indoxyl sulfate.

Savira F, Kompa AR, Kelly DJ, Magaye R, Xiong X, Huang L, Liew D, Reid C, Kaye D, Scullino CV, Pitson SM, Flynn BL, Wang BH. Savira F, et al. Among authors: flynn bl. Vascul Pharmacol. 2021 Dec;141:106923. doi: 10.1016/j.vph.2021.106923. Epub 2021 Sep 29. Vascul Pharmacol. 2021. PMID: 34600152

7

Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes.

Aurelio L, Valant C, Flynn BL, Sexton PM, Christopoulos A, Scammells PJ. Aurelio L, et al. Among authors: flynn bl. J Med Chem. 2009 Jul 23;52(14):4543-7. doi: 10.1021/jm9002582. J Med Chem. 2009. PMID: 19514747

8

The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptor.

Aurelio L, Christopoulos A, Flynn BL, Scammells PJ, Sexton PM, Valant C. Aurelio L, et al. Among authors: flynn bl. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3704-7. doi: 10.1016/j.bmcl.2011.04.080. Epub 2011 May 4. Bioorg Med Chem Lett. 2011. PMID: 21612922

9

5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers.

Aurelio L, Figler H, Flynn BL, Linden J, Scammells PJ. Aurelio L, et al. Among authors: flynn bl. Bioorg Med Chem. 2008 Feb 1;16(3):1319-27. doi: 10.1016/j.bmc.2007.10.065. Epub 2007 Oct 23. Bioorg Med Chem. 2008. PMID: 17980606

10

Effects of conformational restriction of 2-amino-3-benzoylthiophenes on A(1) adenosine receptor modulation.

Aurelio L, Valant C, Flynn BL, Sexton PM, White JM, Christopoulos A, Scammells PJ. Aurelio L, et al. Among authors: flynn bl. J Med Chem. 2010 Sep 23;53(18):6550-9. doi: 10.1021/jm1008538. J Med Chem. 2010. PMID: 20806896

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