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Lansoprazole (LPZ) reverses multidrug resistance (MDR) in cancer through impeding ATP-binding cassette (ABC) transporter-mediated chemotherapeutic drug efflux and lysosomal sequestration.
Ji N, Li H, Zhang Y, Li Y, Wang P, Chen X, Liu YN, Wang JQ, Yang Y, Chen ZS, Li Y, Wang R, Kong D. Ji N, et al. Among authors: chen x. Drug Resist Updat. 2024 Jun 4;76:101100. doi: 10.1016/j.drup.2024.101100. Online ahead of print. Drug Resist Updat. 2024. PMID: 38885537
Triptolide and its pro-drug Minnelide target high-risk MYC amplified medulloblastoma in preclinical models.
Rodriguez-Blanco J, Salvador AD, Suter RK, Swiderska-Syn M, Palomo-Caturla I, Kliebe V, Shahani P, Peterson K, Turos-Cabal M, Vieira ME, Wynn DT, Howell AJ, Yang F, Ban Y, McCrea HJ, Zindy F, Danis E, Vibhakar R, Jermakowicz A, Martin V, Coss CC, Harris BT, de Cubas A, Chen XS, Barnoud T, Roussel MF, Ayad NG, Robbins DJ. Rodriguez-Blanco J, et al. Among authors: chen xs. J Clin Invest. 2024 Jun 11:e171136. doi: 10.1172/JCI171136. Online ahead of print. J Clin Invest. 2024. PMID: 38885332
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