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Mechanisms of thyrotropin receptor-mediated phenotype variability deciphered by gene mutations and M453T-knockin model.
Makkonen K, Jännäri M, Crisóstomo L, Kuusi M, Patyra K, Melnyk V, Linnossuo V, Ojala J, Ravi R, Löf C, Mäkelä JA, Miettinen P, Laakso S, Ojaniemi M, Jääskeläinen J, Laakso M, Bossowski F, Sawicka B, Stożek K, Bossowski A, Kleinau G, Scheerer P, FinnGen F, Reeve MP, Kero J. Makkonen K, et al. Among authors: laakso m. JCI Insight. 2024 Jan 9;9(4):e167092. doi: 10.1172/jci.insight.167092. JCI Insight. 2024. PMID: 38194289 Free PMC article.
SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase.
Kettunen P, Lesnikova A, Räsänen N, Ojha R, Palmunen L, Laakso M, Lehtonen Š, Kuusisto J, Pietiläinen O, Saber SH, Joensuu M, Vapalahti OP, Koistinaho J, Rolova T, Balistreri G. Kettunen P, et al. Among authors: laakso m. J Virol. 2023 Apr 27;97(4):e0014423. doi: 10.1128/jvi.00144-23. Epub 2023 Apr 11. J Virol. 2023. PMID: 37039676 Free PMC article.
LMNA Mutation c.917T>G (p.L306R) Leads to Deleterious Hyper-Assembly of Lamin A/C and Associates with Severe Right Ventricular Cardiomyopathy and Premature Aging.
Alastalo TP, West G, Li SP, Keinänen A, Helenius M, Tyni T, Lapatto R, Turanlahti M, Heikkilä P, Kääriäinen H, Laakso M, Mauermann M, Herrmann H, Pihkala J, Taimen P. Alastalo TP, et al. Among authors: laakso m. Hum Mutat. 2015 Jul;36(7):694-703. doi: 10.1002/humu.22793. Epub 2015 Jun 1. Hum Mutat. 2015. PMID: 25820511
The FADS1 rs174550 Genotype Modifies the n-3 and n-6 PUFA and Lipid Mediator Responses to a High Alpha-Linolenic Acid and High Linoleic Acid Diets.
Meuronen T, Lankinen MA, Kolmert J, de Mello VD, Sallinen T, Ågren J, Virtanen KA, Laakso M, Wheelock CE, Pihlajamäki J, Schwab U. Meuronen T, et al. Among authors: laakso m. Mol Nutr Food Res. 2022 Dec;66(24):e2200351. doi: 10.1002/mnfr.202200351. Epub 2022 Nov 11. Mol Nutr Food Res. 2022. PMID: 36367234 Free PMC article. Clinical Trial.
Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease.
Darci-Maher N, Alvarez M, Arasu UT, Selvarajan I, Lee SHT, Pan DZ, Miao Z, Das SS, Kaminska D, Örd T, Benhammou JN, Wabitsch M, Pisegna JR, Männistö V, Pietiläinen KH, Laakso M, Sinsheimer JS, Kaikkonen MU, Pihlajamäki J, Pajukanta P. Darci-Maher N, et al. Among authors: laakso m. EBioMedicine. 2023 Jun;92:104620. doi: 10.1016/j.ebiom.2023.104620. Epub 2023 May 22. EBioMedicine. 2023. PMID: 37224770 Free PMC article.
Dietary n-3 alpha-linolenic and n-6 linoleic acids modestly lower serum lipoprotein(a) concentration but differentially influence other atherogenic lipoprotein traits: A randomized trial.
Nuotio P, Lankinen MA, Meuronen T, de Mello VD, Sallinen T, Virtanen KA, Pihlajamäki J, Laakso M, Schwab U. Nuotio P, et al. Among authors: laakso m. Atherosclerosis. 2024 Apr 23:117562. doi: 10.1016/j.atherosclerosis.2024.117562. Online ahead of print. Atherosclerosis. 2024. PMID: 38714425 Free article.
A nationwide study on parathyroid carcinoma.
Ryhänen EM, Leijon H, Metso S, Eloranta E, Korsoff P, Ahtiainen P, Kekäläinen P, Tamminen M, Ristamäki R, Knutar O, Löyttyniemi E, Niskanen L, Väisänen M, Heiskanen I, Välimäki MJ, Laakso M, Haglund C, Arola J, Schalin-Jäntti C. Ryhänen EM, et al. Among authors: laakso m. Acta Oncol. 2017 Jul;56(7):991-1003. doi: 10.1080/0284186X.2017.1306103. Epub 2017 Mar 31. Acta Oncol. 2017. PMID: 28362521
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models.
Wittrahm R, Takalo M, Kuulasmaa T, Mäkinen PM, Mäkinen P, Končarević S, Fartzdinov V, Selzer S, Kokkola T, Antikainen L, Martiskainen H, Kemppainen S, Marttinen M, Jeskanen H, Rostalski H, Rahunen E, Kivipelto M, Ngandu T, Natunen T, Lambert JC, Tanzi RE, Kim DY, Rauramaa T, Herukka SK, Soininen H, Laakso M, Pike I, Leinonen V, Haapasalo A, Hiltunen M. Wittrahm R, et al. Among authors: laakso m. Neurobiol Dis. 2023 Jun 15;182:106140. doi: 10.1016/j.nbd.2023.106140. Epub 2023 Apr 28. Neurobiol Dis. 2023. PMID: 37120095 Free article.
1,375 results