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Ten-Gram-Scale Total Synthesis of the Anticancer Drug Candidate E7130 to Supply Clinical Trials.
Kaburagi Y, Kira K, Yahata K, Iso K, Sato Y, Matsuura F, Ohashi I, Matsumoto Y, Isomura M, Sasaki T, Fukuyama T, Miyashita Y, Azuma H, Iida D, Ishida T, Itano W, Matsuda M, Matsukura M, Murai N, Nagao S, Seki M, Yamamoto A, Yamamoto Y, Yoneda N, Watanabe Y, Kamada A, Kayano A, Tagami K, Asano O, Owa T, Kishi Y. Kaburagi Y, et al. Org Lett. 2024 Apr 12;26(14):2837-2842. doi: 10.1021/acs.orglett.3c03663. Epub 2024 Jan 22. Org Lett. 2024. PMID: 38252895
A landmark in drug discovery based on complex natural product synthesis.
Kawano S, Ito K, Yahata K, Kira K, Abe T, Akagi T, Asano M, Iso K, Sato Y, Matsuura F, Ohashi I, Matsumoto Y, Isomura M, Sasaki T, Fukuyama T, Miyashita Y, Kaburagi Y, Yokoi A, Asano O, Owa T, Kishi Y. Kawano S, et al. Among authors: kaburagi y. Sci Rep. 2019 Jun 17;9(1):8656. doi: 10.1038/s41598-019-45001-9. Sci Rep. 2019. PMID: 31209263 Free PMC article.
Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models.
Matsukawa T, Yagi T, Uchida T, Sakai M, Mitsushima M, Naganuma T, Yano H, Inaba Y, Inoue H, Yanagida K, Uematsu M, Nakao K, Nakao H, Aiba A, Nagashima Y, Kubota T, Kubota N, Izumida Y, Yahagi N, Unoki-Kubota H, Kaburagi Y, Asahara SI, Kido Y, Shindou H, Itoh M, Ogawa Y, Minami S, Terauchi Y, Tobe K, Ueki K, Kasuga M, Matsumoto M. Matsukawa T, et al. Among authors: kaburagi y. JCI Insight. 2023 Sep 8;8(17):e161282. doi: 10.1172/jci.insight.161282. JCI Insight. 2023. PMID: 37681411 Free PMC article.
Independent risk factors of rapid glomerular filtration rate decline in patients with type 2 diabetes with preserved kidney function and normoalbuminuria: A multicenter cohort study.
Hirano D, Unoki-Kubota H, Imasawa T, Yamamoto-Honda R, Kajio H, Yamashita S, Fukazawa Y, Seki N, Noda M, Kaburagi Y. Hirano D, et al. Among authors: kaburagi y. J Diabetes Investig. 2023 Jul;14(7):874-882. doi: 10.1111/jdi.14011. Epub 2023 Apr 6. J Diabetes Investig. 2023. PMID: 37026171 Free PMC article.
Podocyte-specific deletion of tubular sclerosis complex 2 promotes focal segmental glomerulosclerosis and progressive renal failure.
Iwata W, Unoki-Kubota H, Kato H, Shimizu A, Matsumoto M, Imasawa T, Igarashi A, Matsumoto K, Noda T, Terauchi Y, Nangaku M, Kasuga M, Kaburagi Y. Iwata W, et al. Among authors: kaburagi y. PLoS One. 2020 Mar 19;15(3):e0229397. doi: 10.1371/journal.pone.0229397. eCollection 2020. PLoS One. 2020. PMID: 32191726 Free PMC article.
109 results