Schofield CJ - Search Results

1

Selective targeting of human TET1 by cyclic peptide inhibitors: Insights from biochemical profiling.

Šimelis K, Saraç H, Salah E, Nishio K, McAllister TE, Corner TP, Tumber A, Belle R, Schofield CJ, Suga H, Kawamura A. Šimelis K, et al. Among authors: schofield cj. Bioorg Med Chem. 2024 Feb 1;99:117597. doi: 10.1016/j.bmc.2024.117597. Epub 2024 Jan 12. Bioorg Med Chem. 2024. PMID: 38262305 Free article.

2

Biochemical and Structural Insights into FIH-Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains.

Saward BG, Leissing TM, Clifton IJ, Tumber A, Timperley CM, Hopkinson RJ, Schofield CJ. Saward BG, et al. Among authors: schofield cj. Chembiochem. 2023 Feb 14;24(4):e202200576. doi: 10.1002/cbic.202200576. Epub 2023 Jan 9. Chembiochem. 2023. PMID: 36448355 Free PMC article.

3

The catalytic domains of all human KDM5 JmjC demethylases catalyse N-methyl arginine demethylation.

Bonnici J, Oueini R, Salah E, Johansson C, Schofield CJ, Kawamura A. Bonnici J, et al. Among authors: schofield cj. FEBS Lett. 2023 Apr;597(7):933-946. doi: 10.1002/1873-3468.14586. Epub 2023 Feb 7. FEBS Lett. 2023. PMID: 36700827 Free PMC article.

4

Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate identification.

Brewitz L, Henry Chan HT, Lukacik P, Strain-Damerell C, Walsh MA, Duarte F, Schofield CJ. Brewitz L, et al. Among authors: schofield cj. Bioorg Med Chem. 2023 Nov 15;95:117498. doi: 10.1016/j.bmc.2023.117498. Epub 2023 Oct 12. Bioorg Med Chem. 2023. PMID: 37857256 Free PMC article.

5

Cyclic β^2,3-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease.

Miura T, Malla TR, Brewitz L, Tumber A, Salah E, Lee KJ, Terasaka N, Owen CD, Strain-Damerell C, Lukacik P, Walsh MA, Kawamura A, Schofield CJ, Katoh T, Suga H. Miura T, et al. Among authors: schofield cj. Bull Chem Soc Jpn. 2024 Mar 6;97(5):uoae018. doi: 10.1093/bulcsj/uoae018. eCollection 2024 May. Bull Chem Soc Jpn. 2024. PMID: 38828441 Free PMC article.

6

Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2.

Liu X, Reinbold R, Liu S, Herold RA, Rabe P, Duclos S, Yadav RB, Abboud MI, Thieffine S, Armstrong FA, Brewitz L, Schofield CJ. Liu X, et al. Among authors: schofield cj. J Biol Chem. 2023 Feb;299(2):102873. doi: 10.1016/j.jbc.2023.102873. Epub 2023 Jan 5. J Biol Chem. 2023. PMID: 36621625 Free PMC article.

7

Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5.

Islam MS, Markoulides M, Chowdhury R, Schofield CJ. Islam MS, et al. Among authors: schofield cj. Sci Rep. 2022 Nov 30;12(1):20680. doi: 10.1038/s41598-022-24154-0. Sci Rep. 2022. PMID: 36450832 Free PMC article.

8

Structure, function, and evolution of metallo-β-lactamases from the B3 subgroup-emerging targets to combat antibiotic resistance.

Krco S, Davis SJ, Joshi P, Wilson LA, Monteiro Pedroso M, Douw A, Schofield CJ, Hugenholtz P, Schenk G, Morris MT. Krco S, et al. Among authors: schofield cj. Front Chem. 2023 Jun 20;11:1196073. doi: 10.3389/fchem.2023.1196073. eCollection 2023. Front Chem. 2023. PMID: 37408556 Free PMC article. Review.

9

Electrochemical Nanoreactor Provides a Comprehensive View of Isocitrate Dehydrogenase Cancer-drug Kinetics.

Herold RA, Schofield CJ, Armstrong FA. Herold RA, et al. Among authors: schofield cj. Angew Chem Int Ed Engl. 2023 Oct 16;62(42):e202309149. doi: 10.1002/anie.202309149. Epub 2023 Sep 12. Angew Chem Int Ed Engl. 2023. PMID: 37607127 Free PMC article.

10

Biochemistry of the hypoxia-inducible factor hydroxylases.

Fiorini G, Schofield CJ. Fiorini G, et al. Among authors: schofield cj. Curr Opin Chem Biol. 2024 Apr;79:102428. doi: 10.1016/j.cbpa.2024.102428. Epub 2024 Feb 7. Curr Opin Chem Biol. 2024. PMID: 38330792 Free article. Review.

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