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A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death.
Mannion J, Gifford V, Bellenie B, Fernando W, Ramos Garcia L, Wilson R, John SW, Udainiya S, Patin EC, Tiu C, Smith A, Goicoechea M, Craxton A, Moraes de Vasconcelos N, Guppy N, Cheung KJ, Cundy NJ, Pierrat O, Brennan A, Roumeliotis TI, Benstead-Hume G, Alexander J, Muirhead G, Layzell S, Lyu W, Roulstone V, Allen M, Baldock H, Legrand A, Gabel F, Serrano-Aparicio N, Starling C, Guo H, Upton J, Gyrd-Hansen M, MacFarlane M, Seddon B, Raynaud F, Roxanis I, Harrington K, Haider S, Choudhary JS, Hoelder S, Tenev T, Meier P. Mannion J, et al. Among authors: harrington k. Immunity. 2024 Jul 9;57(7):1514-1532.e15. doi: 10.1016/j.immuni.2024.04.025. Epub 2024 May 23. Immunity. 2024. PMID: 38788712 Free article.
Long-term memory in wild falcons.
Harrington KJ, Auersperg AMI, Biondi L, Lambert ML. Harrington KJ, et al. Curr Biol. 2024 Sep 9;34(17):R814-R815. doi: 10.1016/j.cub.2024.07.012. Curr Biol. 2024. PMID: 39255762
Oxygen-enhanced MRI detects incidence, onset and heterogeneity of radiation-induced hypoxia modification in HPV-associated oropharyngeal cancer.
Dubec MJ, Price J, Berks M, Gaffney J, Little RA, Porta N, Sridharan N, Datta A, McHugh DJ, Hague CJ, Cheung S, Manoharan P, van Herk M, Choudhury A, Matthews JC, Parker GJM, Buckley DL, Harrington KJ, McPartlin A, O'Connor JPB. Dubec MJ, et al. Among authors: harrington kj. Clin Cancer Res. 2024 Aug 15. doi: 10.1158/1078-0432.CCR-24-1170. Online ahead of print. Clin Cancer Res. 2024. PMID: 39142654
Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy.
Patin EC, Nenclares P, Chan Wah Hak C, Dillon MT, Patrikeev A, McLaughlin M, Grove L, Foo S, Soliman H, Barata JP, Marsden J, Baldock H, Gkantalis J, Roulstone V, Kyula J, Burley A, Hubbard L, Pedersen M, Smith SA, Clancy-Thompson E, Melcher AA, Ono M, Rullan A, Harrington KJ. Patin EC, et al. Among authors: harrington kj. Nat Commun. 2024 Aug 13;15(1):6923. doi: 10.1038/s41467-024-51236-6. Nat Commun. 2024. PMID: 39134540 Free PMC article.
Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell receptor signalling.
Armstrong E, Chiu MKL, Foo S, Appleton L, Nenclares P, Patrikeev A, Mohan N, Mclaughlin M, Bozhanova G, Hoebart J, Roulstone V, Patin E, Pedersen M, Kyula J, Ono M, Errington-Mais F, Bell J, Harrington KJ, Melcher A, Jennings V. Armstrong E, et al. Among authors: harrington kj. J Immunother Cancer. 2024 Jul 25;12(7):e009443. doi: 10.1136/jitc-2024-009443. J Immunother Cancer. 2024. PMID: 39060020 Free PMC article.
A systematic review of antibody-drug conjugates and bispecific antibodies in head and neck squamous cell carcinoma and nasopharyngeal carcinoma: Charting the course of future therapies.
Jiménez-Labaig P, Rullan A, Hernando-Calvo A, Llop S, Bhide S, O'Leary B, Braña I, Harrington KJ. Jiménez-Labaig P, et al. Among authors: harrington kj. Cancer Treat Rev. 2024 Jul;128:102772. doi: 10.1016/j.ctrv.2024.102772. Epub 2024 May 26. Cancer Treat Rev. 2024. PMID: 38820656
415 results