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High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan.
Gao AW, Alam GE, Zhu Y, Li W, Katsyuba E, Sulc J, Li TY, Li X, Overmyer KA, Lalou A, Mouchiroud L, Sleiman MB, Cornaglia M, Morel JD, Houtkooper RH, Coon JJ, Auwerx J. Gao AW, et al. Among authors: morel jd. bioRxiv [Preprint]. 2024 Jan 16:2024.01.15.575638. doi: 10.1101/2024.01.15.575638. bioRxiv. 2024. Update in: Cell Rep. 2024 Oct 22;43(10):114836. doi: 10.1016/j.celrep.2024.114836. PMID: 38293129 Free PMC article. Updated. Preprint.
Genetic background and sex control the outcome of high-fat diet feeding in mice.
Bachmann AM, Morel JD, El Alam G, Rodríguez-López S, Imamura de Lima T, Goeminne LJE, Benegiamo G, Loric S, Conti M, Sleiman MB, Auwerx J. Bachmann AM, et al. Among authors: morel jd. iScience. 2022 May 25;25(6):104468. doi: 10.1016/j.isci.2022.104468. eCollection 2022 Jun 17. iScience. 2022. PMID: 35677645 Free PMC article.
The mouse metallomic landscape of aging and metabolism.
Morel JD, Sauzéat L, Goeminne LJE, Jha P, Williams E, Houtkooper RH, Aebersold R, Auwerx J, Balter V. Morel JD, et al. Nat Commun. 2022 Feb 1;13(1):607. doi: 10.1038/s41467-022-28060-x. Nat Commun. 2022. PMID: 35105883 Free PMC article.
Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging.
Lima TI, Laurila PP, Wohlwend M, Morel JD, Goeminne LJE, Li H, Romani M, Li X, Oh CM, Park D, Rodríguez-López S, Ivanisevic J, Gallart-Ayala H, Crisol B, Delort F, Batonnet-Pichon S, Silveira LR, Sankabattula Pavani Veera Venkata L, Padala AK, Jain S, Auwerx J. Lima TI, et al. Among authors: morel jd. Sci Transl Med. 2023 May 17;15(696):eade6509. doi: 10.1126/scitranslmed.ade6509. Epub 2023 May 17. Sci Transl Med. 2023. PMID: 37196064
The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression.
Benegiamo G, von Alvensleben GVG, Rodríguez-López S, Goeminne LJE, Bachmann AM, Morel JD, Broeckx E, Ma JY, Carreira V, Youssef SA, Azhar N, Reilly DF, D'Aquino K, Mullican S, Bou-Sleiman M, Auwerx J. Benegiamo G, et al. Among authors: morel jd. J Exp Med. 2023 Apr 3;220(4):e20221738. doi: 10.1084/jem.20221738. Epub 2023 Feb 14. J Exp Med. 2023. PMID: 36787127 Free PMC article.
High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan.
Gao AW, El Alam G, Zhu Y, Li W, Sulc J, Li X, Katsyuba E, Li TY, Overmyer KA, Lalou A, Mouchiroud L, Sleiman MB, Cornaglia M, Morel JD, Houtkooper RH, Coon JJ, Auwerx J. Gao AW, et al. Among authors: morel jd. Cell Rep. 2024 Oct 22;43(10):114836. doi: 10.1016/j.celrep.2024.114836. Epub 2024 Oct 4. Cell Rep. 2024. PMID: 39368088 Free article.
Systems genetics of metabolic health in the BXD mouse genetic reference population.
Li X, Morel JD, Sulc J, De Masi A, Lalou A, Benegiamo G, Poisson J, Liu Y, Von Alvensleben GVG, Gao AW, Bou Sleiman M, Auwerx J. Li X, et al. Among authors: morel jd. Cell Syst. 2024 Jun 19;15(6):497-509.e3. doi: 10.1016/j.cels.2024.05.006. Epub 2024 Jun 11. Cell Syst. 2024. PMID: 38866010 Free article.
21 results